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Flashcards in Rad Onc. Deck (16):
1

how does ionizing radiation work

damages DNA

2

2 uses of rad.

1. kill CA cells
2. shrink tumors

3

2 classes of particles used

1. uncharged (photons/neutrons)
2. charged (protons)

4

** what are 2 types of damages caused by radiation

1. direct - directly strikes DNA and damages
2. indirect - strikes water and forms O2 radicals that then damage DNA crosslinks

5

4 downstream effects of radiation

1. pertubation of cell homeostasis
2. cytokine release
3. anti-angiogenisis molecule
4. induced apoptosis

6

3 treatment approaches

1. radical/curative - high dose
2. neo-adjuvant/adjuvant - moderate/high dose
3. palliative

7

3 delivery modalities

1. external beam
2. brachytherapy
3. systemic

8

stages of radiation

1. immobilize
2. simulation
3. planning
4. quality assurance checks
5. treatment delivery

9

what is used for simulation

CT +/- MRI and PET

10

*** 3 factors to consider for radiation

1. patient factors
2. tumor factors - is it sensitive
3. normal tissue factors - can we reach it without hitting other stuff in unsafe manner

11

** big patient factor

ablity to cooperate, performance status

12

what is dose and fractioning

1. dose - amount in total
fractioning - how it will be broken up

13

what are SE of radiation

acute - burns etc
subacute - irritations
chronic - risk of CA

14

what is one SE for everyone

fatugue - cytokines

15

2 types of treatment for brain tumor

surgery - or radiosurgery
- whole brain radiation

16

SE of whole brain radiation

- fatigue
- hair loss
- headache
- nausea
seizure

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