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Flashcards in Peds neoplasia Deck (17):
1

most common CA in children

1. hematopoetic
2. primary brain

2

def. blastoma

malignant cells with primitive (embryonic features)

3

what do blastomas look like

small blue cells

4

3 genetic mechs in pediatric neoplasm

1. activations of oncogene
2. loss of tumor supressor gene
3. creation of novel fusion protein

5

what is ewing sarcoma CA

bone - small round blue cell

6

what are neuroblastic tumors

early childhood
- 70% have mets at diagnosis
- often adrenal medulla

7

what are names of malignant and benight neuroblastic tumors

mal - neuroblastoma
benigh - ganglioneuroma

8

what defines a ganglioneuroma

well differentiated

9

3 features of differentiation in neuroblastoma

1. neuropil
2. ganglion cell differentiation
3. schwannian stroma (stroma rich or poor)

10

what is common genetic issue in neuroblastoma (2)

1. MYCN amplification
2. deletion of 1p

11

** 5 major prognostic factors for neuroblastoma

1. age at diagnosis (under 18mo better)
2. clinical stage
3. histoloy (differentiation)
4. tumor DNA (aneuplois better than diploid)
5. MYC amplification (bad)

12

what is most common ped. kidney tumor

wilms

13

what is wilms

- from metanephric blastema
- mimics dev. kidney

14

what is triphasic pattern of wilms

1. epithelial
2. stromal
3. blastemal

15

precursor to neuroblastoma

nephrogenic rest

16

2 major prognostic factots for nephroblastoma

1. stage
2. histology

17

def. anaplasia

1. cell and nuclear enlargement
2. nuclear hyperchromasia
3. multipolar and abnormal mitoses

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