Pancreatic exocrine Flashcards Preview

Undeleted > Pancreatic exocrine > Flashcards

Flashcards in Pancreatic exocrine Deck (21):
1

2 main functional structures of pancreas

1. endocrine - islets of langerhan
2. exocrine - acinar and duct cells

2

2 exocrine glands and their products

1. acinar - enzymes
2. duct cells - HCO3

3

reason for HCO3 excretion (2)

1. neutralizes chyme to protect duod
2. optimizes pH for enzymes

4

path for Cl excretion in duct cell

1. stim. by secretin
2. increases cAMP
3. CFTR channel unfolds
4. Cl excreted out
5. Na follows Cl
6. H20 follows Na

5

what is acidic tide

when duct secretes HCO3 into lumen, it puts H+ into blood, which neutralizes HCO3 from stomach

6

what happens in alc. induces pancreatitis

reduced HCO3 and H20 secretion

7

what happens in cystic fibrosis

CFTR mutation means Cl doesn't leave and no H2O

8

how does this lead to pancreatitis

reduced flow> thickening forms plugs> inflammation and fibrosis> necrosis and atrophy

9

where are enzymes made in acinar cell

ER and stored in vacuoles

10

what controls acinar release

exosytosis is under physiological control, not production

11

what are 3 phase of pnacreatic secretion

1. cephalic - vagus
2. gastric - chemo and mechno recptors
3. intestinal (majority) - hormone and vaso-vagal

12

what are 2 cephalic pathways of panc. secretions

1. direct vagal stim of cells via ACH
2. vagal stim of gastrin> stims panc. cells

13

2 hormones of intestinal phase

1. secretin - release by S cells in response to acid
2. cholecystokinin (CCK) - released by I cells in response to fat and digested proteins

14

what do 2 hormones do

1. secretin - direct stim to make HCO3
2. CCK - indirect stim via vagal to make enzymes

15

path of CCK

fat>I cells make CCK>vagus nerve releases ACH>acinar cells make enzymes>enzymes make trypsin which inhibs CCK

16

path of secretin

acid stims S cells> secrete secreting> ductal cells resnd with HCO3 and H2O

17

in what form are enzymes secreted

zymogens tha are then cleaved to active form to make enzyme

18

how are zymogens activated

1. activating enzymes
2. active form can activate inactive forms

19

names of zymogens

pro____ or _____ogen

20

what happens in abnormal pnacreas

lysozomes and zymogens together to make active form - autodigest

21

3 ways prevent autodigestion

1. separate packages
2. store enzymes as zymogens
3. anti-proteases inside zymogen granules

Decks in Undeleted Class (589):