Intro pharmacology and pharmacokinetics Flashcards Preview

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Flashcards in Intro pharmacology and pharmacokinetics Deck (25):
1

def. of therapeutics

treatment of diseases

2

top 5 reasons for PT visits

1. HT
2. Diabetes
3. Check-up
4. Depression
5. Anxiety

3

% of visits getting drugs

59%

4

5 main classes of drugs

1. natural preparations
2. pure compunds - morphine
3. semi-synthetics - heroin
4. purely synthetic - most modern drugs
5. biological products - many cancer drugs

5

what is chemical name

describes the chemical structure

6

what is drug company code

used by pharma in early dev.

7

what is generic name

officially approved name - ibuprofen

8

what is proprietory name

brand name - advil

9

what is street name

used on the street - exctacy

10

2 key areas of pharmacology and define

1. phramacokinetic - what body does to drug
2. pharmacodynamics - what drug does to body

11

2 main steps in figuring out drugs

1. what is drug taget and agent
2. how do we get the drug there

12

factors to take into account about drug

1. efficacy
2. safety
3. route of admin
4. route of elim
5. cost

13

factors to take into account with person

1. demographics
2. medical conditions
3. personal factors

14

Path of drugs in body

ADME
Absorbed
Distributed (redistributed)
Metabolized
Excreted

15

2 main types of drug admin

1. enteral - in the gut
2. parenteral - beside the gut (skin, blood)

16

diff between topical and transdermal

topical - one spot only
transdermal - through the skin to system

17

where are most orally drugs absorbed

small intestine

18

what is first pass effect

biotransformation of drug (active or inactive ) before it reaches the site of action

19

main place of transformaiton

liver

20

what does first pass effect affect

bioavailability

21

what is bioavailability

% of drug that reaches the site of action unchanged - comparison of route to IV route

22

what is calculation for bioavailability

AUCextravascular/AUCintravenous

23

what is bioequivalence

basically that a new drug is used in the same way as the one it is trying to replace

24

what is therapeutic equivalence

comparable clinical effectiveness between drug products

25

what is a prodrug

drug itself is active, but body transforms to active form

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