Carbo metabolism Flashcards Preview

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Flashcards in Carbo metabolism Deck (25):
1

what are glucagon and epi effects on insulin

antagonsist

2

how is ATP used in muscle

1 ATP to allow myosin to pull

3

what is use of creatine phosphate

storage in muscle that can be cleaved for an ATP by creatine kinase

4

what do we rely on for longer term ATP

glycogen and fat reserves

5

how does glucose get into muscle cell

GLUT4 transporter

6

steps of glycolysis

1. 6C glucose to 2 3C sugars with ATP invest
2. each 3C sugar to2 ATP and NADH
3. final product is pyruvate which can go into the kreb cycle in mito

7

where does glycolysis occur

in cytoplasm

8

what happens to pyruvate in mito

1. pyruvate to Acetyl CoA
2. enter krebs
3. e transport chain
4. O is final e acceptor
5. oxidative phosphrylation leading to ATP and H2O

9

3 ways if getting ATP in muscles

1. glycollysis
2. PDH complex
3. krebs

10

what does krebs use Acetyl CoA to form at end

oxaloacetate

11

what is total ATP production pr glucose

30ATP/glucose

12

what are potential fates of pyruvate

1. fat as Acetyl CoA
2. oxaloacetate for TCA = ATP
3. alanine synthesis - if not avail in diet
4. anarobic fermentation (not humans)
5. to lactate via anarobic resp

13

what cause anarobic cramping

drop in pH due to ATP hydrolysis, not lactic acid

14

what converts pyruvate to lactate

lactate dehydrogenase

15

what can liver do to lactate

make into glucose by gluconeogenisis

16

what happens to muscle cell with epi

GCPR leads to cAMP to eventually initiate glycogen phosphorylase

17

what does glycogen phosphorylase do

cleave glucose off glycogens to then enter glycoloysis

18

what is danger of falling blood glucose

brain can't make own glucose, so depends on it from the blood

19

what does falling blood glucose trigger

glucagon rellease from a cells in pancreas

20

what does glucagon do?

leads to glucose release from liver

21

what is mech of glucagon at liver

GCPR to create glucose 1 phospate

22

what does Glc-1-P do?

hydrolizes off a glucose that will then be sent off into the blood

23

what is second function of liver PKA

turns off glycogen synthesis so we dont make it and break it

24

what is gluconeogenisis

anabolic liver pathway by which pyruvate is converted to glucose

25

3 potential sources for liver to glucogenisis

1. lactate
2. AAs
3. glycerol

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