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Flashcards in Parenchymal diseases Deck (15):
1

3 types of parenchmal diseases

1. glomerular
2. tubointerstitial
3. vascular

2

what is glomerular funciton

filtration (GFR)
barrier to cells and proteins

3

clues to a renal level disease

1. systemic features
2. HT
3. mild-mod ECF overload
4. anemia/thrombopenia

4

**2 clinical presentations of glomerular disease

1. nephotic syndrome
2. nephritic

5

4 features of nephrotic

HELP
1. Hypoalbumen
2. Edema
3. Lipidemia
4. Proteirnuria >3.5/day
NON-proliferative
- can ONLY be caused by glomerular disease

6

4 features of nephritic disease

1. HT
2. hematuria
3. proteinuria - small
4. acute kidney injury
PROLIFERATIVE

7

what is patho classification of glomerular disease

1. non-prolif.
- glomerulonephroPATHY
- present with nephrotic syndrome
2. prolif
- glomerulonephITIS
- presents with nephritis syndrome
-RBC casts
- EMERGENCY

8

4 causes of cell prolif.

1. deposition of immune complexes
- post -infecious
- SLE
- Hep, HIV
2. AB depsition within glomerulus
3. dysregulation of complement system
4. idio

9

what is work-up for prolif

- look for the things that could be causing
- biopsy

10

3 different patho types of prolif

1. mesangial cell
2. endothelial
3. epithelial

11

main cause of mesangial cell

IgA neprhopathy
- HIV, cirrossis, celiac

12

2 main causes of endo

1. lupus
2. post-infectious glomerulonephritis

13

2 potential outcome of lupis

1. proliferative
2. non-proliferative
-depends on where complexes get stuck

14

patho feature of epithelial

cresenctric GNs
- most aggresive form of glomerular disease

15

3 main patho sub-types of epithelial

1. linear GBM staining - anti GMB disease
2. coarse/granular staining
- SLE
- post-infesctious
3. little or no stain
- ANCA vasculitis

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