diabetes from physiology to clinical practice Flashcards Preview

Undeleted > diabetes from physiology to clinical practice > Flashcards

Flashcards in diabetes from physiology to clinical practice Deck (20):
1

2 main DM trials and for what

1. diabetes complication and control trial (DCCT) - type 1 - also EDIC follow up
2. UK prospective diabetes study (UKDPS) - type 2

2

2 groups in DCCT

1. promary prevention (no Sx)
2. secondary prevention (minor Sx)

3

2 intervention in DCCT

1. regular insulin injection
2. intensive injection

4

finding from DCCT

major improvments in retinopathy, nephropathy, neuropathy

5

SE of intensive treatment (2)

1. frequenct hypoglycemia
2. slight weight gain

6

2 main findings from EDIC

1. intensive intervention reduced macro events
2. slows progression of events, but doesn't prevent it

7

question asked by UKDPS

does intensive glucose control help in DM2

8

UKPDS findings

reduced HBA1C and reduced negative outcomes

9

3 steps for DM2 treatment

1. improve insulin sensitivity - diet, exercise, metformin
2. counteract insulin deficiency - secretogogues
3. if given up - insulin therapy

10

what are 2 insulin sensitizers

1. biguanide
2. thiazolidiones

11

what do insulin sensitizers do (2)

1. lower glucose production
2. increase muscle uptake

12

what are 2 secretagagues and what do they do

sulfonyureas and meglinitides - increae insulin secretion

13

how can renal clearance of glucose be increased

SGLT-2 inhibitors

14

what do mimetics do (2)

1. lower glucose production
2. incr. insulin secretion

15

main SE of secretagogues

hypoglycemia

16

2 major classes of SE of secretagpgues and insulin induced hypoglycemia

1. andrenergic Sx - anxiety, hunger, confucsion, sweating
2. neruoglycopenic - seizure, coma, somnolence

17

what is disadvantage to regular insulin injection

not absorbed right away and get hypoglycemia

18

what is faster acting insulin (3)

1. lispro
2. aspart

19

what is combo therapy

1. give long acting - glargine, detemir
2. fast acting bolus with meals

20

how can combo therapy be improved

insulin pump

Decks in Undeleted Class (589):