AUTONOMIC PHARMACOLOGY Flashcards Preview

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Flashcards in AUTONOMIC PHARMACOLOGY Deck (77)
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1

T1 - T12
L1 - L5

Sympathetic/Thoracolumbar

2


CN 3,7,9,10
S2-S4

Parasympathetic
(Craniosacral)

3

SYMPATHETIC (SANS)
Preganglionic fibers originate from

Thoracic (T1 -T12) segments of the cord
Lumbar (L1 -L5) segments of the cord

4

PARASYMPATHETIC (PANS)
Preganglionic motor fibers originate from

Cranial nerve nuclei III, VII, IX and X
Sacral segments (S2-S4)

5

Preganglionic fibers are short and the
postganglionic fibers are long

SYMPATHETIC

6

Few (prevertebral) on the anterior aspect of the
aorta

SYMPATHETIC

7

Most of the ganglia are located in 2 paravertebral
chains that lie along the spinal cord

SYMPATHETIC

8


Most of the ganglia are located in the organs
innervated, most distant from the spinal cord

PARASYMPATHETIC

9

Preganglionic fibers are long and the
postganglionic fibers are short

PARASYMPATHETIC

10

NEUROTRANSMITTERS (NTAs)
4 FEATURES

1. Synthesis
2. Storage
3. Release
4. Termination of action

11

NEUROTRANSMITTERS
TERMINATION OF ACTION

By metabolism
-Monoamine oxidase (MAO)
-Cathecol-o-methly transferase (COMT)
Diffuse away from the synaptic cleft and get metabolized elsewhere

12


A nerve ending that releases acetylcholine as
the primary transmitter
Also a synapse in which acetylcholine is the
primary transmitter

CHOLINERGIC

13


A nerve ending that releases norepinephrine as
the primary transmitter
Also a synapse in which norepinephrine is the
primary transmitter

ADRENERGIC

14

All preganglionic fibers are

cholinergic

15

All postganglionic parasympathetic fibers are

cholinergic

16

A few postganglionic sympathetic fibers are

cholinergic

17

Most postganglionic sympathetic fibers are

adrenergic

18

Exception: Postganglionic sympathetic fibers
are

cholinergic

19


Adrenal cortex and medulla
Ductless gland that functions as a ganglion
Postganglionic fibers are cholinergic

ADRENAL GLAND

20

Inhibits transport/synthesis of ACh into the cell

HEMICHOLINIUM

21


Inhibits storage of ACh into the vesicle

VESAMICOL

22


Inhibits the release of ACh

BOTULINUM TOXIN

23

These drugs (Hemicholinium, vesamicol, botulinum toxin) are not very useful for systemic therapy
because their

effects are not sufficiently selective

24


Inhibits the synthesis of NE

METYROSINE

25

Inhibits the storage of NE

RESERPINE

26

These drugs (METYROSINE, RESERPINE, GUANETHEDINE, MAO I) have been used in several diseases because

they block sympathetic but not parasympathetic functions

27

Inhibits release of NE

GUANETHEDINE

28

Inhibits metabolism of NE

MAO I

29


Other transmitter molecules in addition to the
primary agents (ACh or NE)
Contained in many autonomic nerves
Localized in the same vesicle as the primary
transmitter or in a separate population of vesicles
Involved in the modulation of synaptic
transmission

COTRANSMITTERS

30


ATP
Enkephalins
VIP
Neuropeptide Y
Substance P
Somatostatin
Neurotensin

COTRANSMITTERS

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