Flashcards in SI LEC - Antigens Deck (46)
macromolecules capable of triggering an adaptive immune response by inducing antibodies or sensitized T cells in an immunocompetent host.
substance that reacts with ab or sensitized T cells but may not be able to evoke an immune response
reasons why we respond to immunogens (3)
Nature of immunogen itself
Genetic coding of MHC molecules that must combine w/ an immunogen before T cells are able to respond
Immunogen processing and presentation
FACTORS INFLUENCING THE IMMUNE RESPONSE
Route of inoculation
TRAITS OF IMMUNOGENS
The ability of immunogens to stimulate a host response depends on the ff:
Chemical composition and molecular complexity
Ability to be processed and presented with MHC molecules
Immunogen must have a MW of at least
The greater the MW, the ___ the immunogenecity.
MW of the best immunogens
Over 100 000 daltons
are best immunogens based on complexity
Proteins and polysaccharides
which is more immunogenic, CHON or CHO
EX of nonimmunogenic based on complexity (3)
pure nucleic acids
usual form of CHO
CHO are usually in the form of glycoproteins (Rh and Lewis ags), glycolipids (ABH antigens)
Ex of glycoproteins
Rh and Lewis Ags
Ex of glycolipids
Pure nucleic acids and lipids must be attached first to a _____ to be immunogenic
are used for artificial heart valves, elbow replacement, and other medical appliances.
_______ better immunogen for an animal than is material for from a related animal.
Any lymphocyte that will ______ will be normally deleted,
react to self Ags
All ____ are considered immunogenic
how are Ags processed
Types of epitope
repeating copies or differing specificities
Molecular shapes or configurations that are recognized by B or T cells
Small part of an immunogen that is actually recognized in the immune response
w/ epitope of 6-15 aa
PROTEINS : w/ epitope of how many aa
recognized both linear and conformational epitopes present on the surface of an immunogen.
recognized epitope only as a part of the complex formed with MHC on the surface of antigen-presenting cells
B cells recognized both ___ (what epitope types) present on the surface of an immunogen.
linear and conformational epitopes
T cells recognized epitope only as ______ on the surface of antigen-presenting cells
a part of the complex formed with MHC