Flashcards in SI LEC - Antigens Deck (46)
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1
macromolecules capable of triggering an adaptive immune response by inducing antibodies or sensitized T cells in an immunocompetent host.
IMMUNOGENS-
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substance that reacts with ab or sensitized T cells but may not be able to evoke an immune response
ANTIGENS-
3
reasons why we respond to immunogens (3)
Nature of immunogen itself
Genetic coding of MHC molecules that must combine w/ an immunogen before T cells are able to respond
Immunogen processing and presentation
4
FACTORS INFLUENCING THE IMMUNE RESPONSE
Age
Overall health
Dose
Route of inoculation
Genetic predisposition
5
TRAITS OF IMMUNOGENS
The ability of immunogens to stimulate a host response depends on the ff:
Molecular size
Chemical composition and molecular complexity
Foreigness
Ability to be processed and presented with MHC molecules
6
Immunogen must have a MW of at least
10,000 daltons.
7
The greater the MW, the ___ the immunogenecity.
more potent
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MW of the best immunogens
Over 100 000 daltons
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are best immunogens based on complexity
Proteins and polysaccharides
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which is more immunogenic, CHON or CHO
CHONS
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EX of nonimmunogenic based on complexity (3)
synthetic polymers
pure nucleic acids
lipids
12
usual form of CHO
CHO are usually in the form of glycoproteins (Rh and Lewis ags), glycolipids (ABH antigens)
13
Ex of glycoproteins
Rh and Lewis Ags
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Ex of glycolipids
ABH Ag
15
Pure nucleic acids and lipids must be attached first to a _____ to be immunogenic
carrier molecule
16
are used for artificial heart valves, elbow replacement, and other medical appliances.
Synthetic polymers
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_______ better immunogen for an animal than is material for from a related animal.
Plant proteins
18
Any lymphocyte that will ______ will be normally deleted,
react to self Ags
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All ____ are considered immunogenic
non self
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how are Ags processed
enzymatic digestion
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Types of epitope
repeating copies or differing specificities
linear/sequential
conformational
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Molecular shapes or configurations that are recognized by B or T cells
EPITOPE
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Small part of an immunogen that is actually recognized in the immune response
EPITOPE
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w/ epitope of 6-15 aa
PROTEINS
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PROTEINS : w/ epitope of how many aa
6-15
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recognized both linear and conformational epitopes present on the surface of an immunogen.
B cells
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recognized epitope only as a part of the complex formed with MHC on the surface of antigen-presenting cells
T cells
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B cells recognized both ___ (what epitope types) present on the surface of an immunogen.
linear and conformational epitopes
29
T cells recognized epitope only as ______ on the surface of antigen-presenting cells
a part of the complex formed with MHC
30
