Flashcards in SI LEC - Innate Immunity Part 2 Deck (63)
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1
Serum Amyloid A assoc with
HDL-Cholesterol
2
Apolipoprotein
MW = ??
11, 685 daltons
3
Normal circulating levels of SAA
30 µg/mL
4
Functions of SAA
Cleaning up chole from macrophages at the site of tissue injuries
Recycles cell membrane cholesterol
5
Series of serum proteins that are normally present
Major functions include:
opsonization
chemotaxis
cytolysis
Complement
6
complement Major functions include:
opsonization
chemotaxis
cytolysis
7
Mannose-Binding Protein also called
Aka mannose-binding lectin
8
Trimer
Acts as an opsonin
Ca-dependent
Mannose-Binding Protein
9
Recognize foreign CHO found on bacteria, yeasts, viruses, parasites
Mannose-Binding Protein
10
Activates C’, helps promote phagocytosis
Mannose-Binding Protein
11
Normal concentration = of MBP
10 µg/mL
12
Uninhibited proteases can remain in lower resp tract and destroy parenchymal cells = development of ___
emphysema
13
endogenous ENZ that degrade elastin and collagen
Elastase :
14
Major component of the alpha band in SPE
Plasma inhibitor of proteases released from WBC (eg. elastase)
Alpha1-antitrypsin
15
Acts a “mop-up” or counteracts the effect of neutrophil invasion during inflammation
Alpha1-antitrypsin
16
Can also react w/ serine proteases triggering C’ cascade or fibrinolysis
Alpha1-antitrypsin
17
Regulates expression of pro-inflammatory cytokines
Alpha1-antitrypsin
18
An Alpha2- globulin
haptoglobin
19
MW of haptoglobin
100 000
20
Binds free hgb (released by intravascular hemolysis) irreversibly
haptoglobin
21
Hgb Haptoglobin complex cleared by
liver
22
haptoglobin levels may ___ because of intravascular hemolysis: must be interpreted in the light of other APR
drop
23
Normal plasma conc= 40 to 290 mg/dL what acute reactant protein
haptoglobin
24
haptoglobin Normal plasma conc
40 to 290 mg/dl
25
Unfolded CHONS __ in blood vessels
aggregate
26
plays a role in protecting kidneys from damage
haptoglobin
27
prevents loss of iron
haptoglobin
28
prevents oxidative damage of free hgb
haptoglobin
29
Most abundant coagulation factor
fibrinogen
30
