SI LEC - Innate Immunity Part 2 Flashcards Preview

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Flashcards in SI LEC - Innate Immunity Part 2 Deck (63)
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1

Serum Amyloid A assoc with

HDL-Cholesterol

2

Apolipoprotein
MW = ??

11, 685 daltons

3

Normal circulating levels of SAA

30 µg/mL

4

Functions of SAA

Cleaning up chole from macrophages at the site of tissue injuries
Recycles cell membrane cholesterol

5

Series of serum proteins that are normally present
Major functions include:
opsonization
chemotaxis
cytolysis

Complement

6

complement Major functions include:

opsonization
chemotaxis
cytolysis

7

Mannose-Binding Protein also called

Aka mannose-binding lectin

8

Trimer
Acts as an opsonin
Ca-dependent

Mannose-Binding Protein

9


Recognize foreign CHO found on bacteria, yeasts, viruses, parasites



Mannose-Binding Protein

10

Activates C’, helps promote phagocytosis

Mannose-Binding Protein

11

Normal concentration = of MBP

10 µg/mL

12

Uninhibited proteases can remain in lower resp tract and destroy parenchymal cells = development of ___

emphysema

13


endogenous ENZ that degrade elastin and collagen

Elastase :

14

Major component of the alpha band in SPE
Plasma inhibitor of proteases released from WBC (eg. elastase)

Alpha1-antitrypsin

15

Acts a “mop-up” or counteracts the effect of neutrophil invasion during inflammation

Alpha1-antitrypsin

16

Can also react w/ serine proteases triggering C’ cascade or fibrinolysis

Alpha1-antitrypsin

17

Regulates expression of pro-inflammatory cytokines

Alpha1-antitrypsin

18

An Alpha2- globulin

haptoglobin

19

MW of haptoglobin

100 000

20

Binds free hgb (released by intravascular hemolysis) irreversibly

haptoglobin

21

Hgb Haptoglobin complex cleared by

liver

22

haptoglobin levels may ___ because of intravascular hemolysis: must be interpreted in the light of other APR

drop

23

Normal plasma conc= 40 to 290 mg/dL what acute reactant protein

haptoglobin

24

haptoglobin Normal plasma conc

40 to 290 mg/dl

25

Unfolded CHONS __ in blood vessels

aggregate

26

plays a role in protecting kidneys from damage

haptoglobin

27

prevents loss of iron

haptoglobin

28

prevents oxidative damage of free hgb

haptoglobin

29

Most abundant coagulation factor


fibrinogen

30

Normal levels= 100 to 400 mg/dL

fibrinogen

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