Flashcards in SI LEC - Innate Immunity Part 2 Deck (63):
1
Serum Amyloid A assoc with
HDL-Cholesterol
2
Apolipoprotein
MW = ??
11, 685 daltons
3
Normal circulating levels of SAA
30 µg/mL
4
Functions of SAA
Cleaning up chole from macrophages at the site of tissue injuries
Recycles cell membrane cholesterol
5
Series of serum proteins that are normally present
Major functions include:
opsonization
chemotaxis
cytolysis
Complement
6
complement Major functions include:
opsonization
chemotaxis
cytolysis
7
Mannose-Binding Protein also called
Aka mannose-binding lectin
8
Trimer
Acts as an opsonin
Ca-dependent
Mannose-Binding Protein
9
Recognize foreign CHO found on bacteria, yeasts, viruses, parasites
Mannose-Binding Protein
10
Activates C’, helps promote phagocytosis
Mannose-Binding Protein
11
Normal concentration = of MBP
10 µg/mL
12
Uninhibited proteases can remain in lower resp tract and destroy parenchymal cells = development of ___
emphysema
13
endogenous ENZ that degrade elastin and collagen
Elastase :
14
Major component of the alpha band in SPE
Plasma inhibitor of proteases released from WBC (eg. elastase)
Alpha1-antitrypsin
15
Acts a “mop-up” or counteracts the effect of neutrophil invasion during inflammation
Alpha1-antitrypsin
16
Can also react w/ serine proteases triggering C’ cascade or fibrinolysis
Alpha1-antitrypsin
17
Regulates expression of pro-inflammatory cytokines
Alpha1-antitrypsin
18
An Alpha2- globulin
haptoglobin
19
MW of haptoglobin
100 000
20
Binds free hgb (released by intravascular hemolysis) irreversibly
haptoglobin
21
Hgb Haptoglobin complex cleared by
liver
22
haptoglobin levels may ___ because of intravascular hemolysis: must be interpreted in the light of other APR
drop
23
Normal plasma conc= 40 to 290 mg/dL what acute reactant protein
haptoglobin
24
haptoglobin Normal plasma conc
40 to 290 mg/dl
25
Unfolded CHONS __ in blood vessels
aggregate
26
plays a role in protecting kidneys from damage
haptoglobin
27
prevents loss of iron
haptoglobin
28
prevents oxidative damage of free hgb
haptoglobin
29
Most abundant coagulation factor
fibrinogen
30
Normal levels= 100 to 400 mg/dL
fibrinogen
31
forms fibrin clots
Fibrinogen
32
trimer
mannose-binding protein
33
dimer
fibrinogen
34
fibrinogen normal levels
100 to 400 mg/dl
35
MW = 340, 000 daltons
fibrinogen
36
MW of fibrinogen
340 000
37
Increases the strength of the wound
Fibrinogen
38
Promotes aggregation of RBCs
can increased risk of developing CAD
Fibrinogen
39
Forms a clot; a barrier to prevent spread of microbes
Fibrinogen
40
Stimulates endothelial cell adhesion and proliferation
Fibrinogen
41
autosomal recessive genetic disorder
Co accumulates in the liver, brain, cornea, kidneys,
Wilson’s dx
42
Acts as ferroxidase
Ceruloplasmin
43
the principal Co-transporting protein in the human plasma
Ceruloplasmin
44
MW= 132, 000 daltons
Ceruloplasmin
45
Binds 90-95% copper found in the plasma
Ceruloplasmin
46
help make neutrophils sticky and enhance adherence to endothelial cells
Selectins:
47
movement thru blood vessel walls.
diapedesis
48
NEUT form __ which squeeze thru junctions
pseudopods
49
chem’l messenger that cause cells to migrate in a particular direction
chemotaxins
50
Life span of neutrophil in the tx:
5 days
51
w/ primary and specific granules
Capable of phagocytosis but not as efficient as neutrophil
Neutralizing basophils and mast cells
Killing parasites
Eosinophils
52
vasoactive amine that contracts smooth muscle
Basophils
53
immunoglobulin that binds to surface of basophil
IgE
54
lifespan of basophils
few hours
55
Basophils that have migrated to the tissues.
Mast Cells
56
Largest in the peripheral blood
Monocytes
57
granules of monocytes (6)
peroxidase
ACP
arylsulfatase
beta-glucuronidase
lysozyme
lipase
58
monocytes Stay in peripheral blood up to ?? hours
70
59
as macrophage become monocytes, there is an increase in __
Increase in ER, lysosomes, and mitochondria
60
w/ progressive cellular enlargement to b/w 25-80 um
tissue macrophage
61
Long lived but slow in motility
monocytes
62
Fxn: microbial killing, tumoricidal, intracellular parasites eradication, phagocytosis, secretion of cytokines, Ag presentation
monocytes
63