Flashcards in HEMA LEC - Intro Lecture Deck (58)
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• 2 Types of PMN
o PMN – mature and segmented
o Neutrophilic bands - immature
2
– immature PMN
bands/ Neutrophilic bands
3
o Shift to the left –
immature
4
o Shift to the right -
mature
5
• with bright orange granules filled with antihistamine
Eosinophils
6
caused by bacterial infection
Neutrophilia:
7
long term drug administration
Neutropenia:
8
theoretical/unused, decrease of eosinophil
• Eosinopenia:
9
allergy, parasitism, increase of eosinophils
• Eosinophilia:
10
•
rare, hematologic disease (leukemia)
• Basophilia:
11
With dark blue granules that obscure the nucleus
basophils
12
• Big round nucleus, thin rim of cytoplasm
• Slightly larger than RBCs
lymphocytes
13
• viral infection
Lymphocytosis:
14
long term drug administration, immunodeficiency
Lymphopenia/lymphocytopenia
15
• Phagocytosis, presentation of epitopes
monocytes
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• Macrophage in tissues
monocytes
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• Slightly larger than other WBCs
monocytes
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rare hematologic disorder
• Monocytosis:
19
theoretical disease of monocytes
• Monocytopenia:
20
• Pieces of a bone marrow cell called megakaryocyte
• Function to stop bleeding by forming a plug and releases coagulation factors (controls hemostasis)
• Forms thrombus (clot)
platelet
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platelet capable of
adhesion, aggregation, secretion
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• 2-4u, oval, anucleated, slightly granular
platelet
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• Reference range of plt
150 – 450 K/cu. Mm
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• High MPV means
regenerative BM response to platelet consumption
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inflammation, trauma
•
Thrombocytosis
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: consequence of treatment
Thrombocytopenia
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HEMATOLOGY TESTS/EXAMINATIONS
1. Erythrocyte Sedimentation Rate
2. Reticulocyte Count
3. Peripheral Blood Examination
4. Sickle Cell Testing
5. Osmotic Fragility Test (OFT)
6. Coagulation Tests include
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6. Coagulation Tests include
a. Prothrombin Time
b. Partial Thromboplastin Time
c. Fibrinogen
d. Factor Analysis
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ADVANCED HEMA PROCEDURES
1. BM Examination
2. Cytogenic analysis
3. Molecular assay
4. Cytochemical stains (differentiate abnormal cells)
5. Flow cytometry
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