BIOCHEM 2 - PROTEIN FUNCTION Flashcards Preview

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Flashcards in BIOCHEM 2 - PROTEIN FUNCTION Deck (76)
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1

Most abundant protein in animals




collagen

2

SOLUBILITY OF COLLAGEN IN WATER

Water-insoluble fibers

3

Location of collagen in the cell

extracellular

4

Has great tensile strength (due to aldol crosslinks)

collagen

5

contributes to great tensile strength of collagen

aldol crosslinks

6

major role of collagen

stress-bearing component of connective tissues

7

location of collagen in body

Cartilage, bones, tendons, ligaments & skin

8

Primary Structure of collagen

-(-X–Y–G-)-
- X–Pro/Hyp; Y–any aa
- each chain is about 800 aa residues long

9

Secondary Structure of collagen

- Left-handed α-helix
- 3.3 aa/turn
- Pitch: 10 Å

10

Tertiary structure

- 3 chains are parallel & wind each other in a right-handed manner to form a triple-helical structure
- H-bond involving Hyp and Hyl residues
- intramolecular and intermolecular aldol covalent crosslinks

11

Structural proteins
Found predominantly in walls of arteries, lungs, intestines and skins

elastin

12

“slide & stretch” over one another to maintain structural integrity and provide recoil

Elastin

13

MW of elastin

MW = 72 kDa;

14

hydrophobicity of elastin

highly hydrophobic

15

Connective tissue protein; has elastic properties



elastin

16

Consists predominantly of nonpolar aa residues, 1/3 G, 1/3 V + A, rich in P

elastin

17

protein having Random coil conformation

elastin

18

protein having Intramolecular and intermolecular desmosine crosslinks

elastin

19

is formed from three allysyl side chains plus one unaltered lysl side chain from the same or neighbouring polypeptide.

A desmosine cross-link

20

responsible for the rubber properties of elastin

A desmosine cross-link

21

Hemeproteins; conjugated proteins

myoglobin
hemoglobin

22

Responsible to the red color of the blood
Prosthetic group (non-protein part)
Porphyrin ring
Centrally bound Fe+2

heme

23

Monomer
Contains a heme




myoglobin

24

primary structure of myoglobin

1 Structure: 153 aa

25

secondary structure of myoglobin

2 Structure: Helical

26

tertiary structure of myoglobin

3 Structure: Globular

27

Found in skeletal and cardiac muscle

myoglobin

28

Folded globin chain forms a crevice which encloses a heme group

myoglobin

29

Heme group of myoglobin is inside the protein since it’s

hydrophobic

30

Roughly spherical molecule found in red blood cells


hemoglobin

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