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Flashcards in beta-lactam: other drugs Deck (64)
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1

Is vancomycin absorbed orally?

no

2

Bactericidal glycoprotein

A. VANCOMYCIN

3

Binds to the D-Ala-D-Ala terminal of the nascent peptidoglycan pentapeptide side chain

A. VANCOMYCIN

4

Inhibits transglycosylation

A. VANCOMYCIN

5

Prevents elongation of peptidoglycan chain

A. VANCOMYCIN

6

Interferes with cross-linking

A. VANCOMYCIN

7

Spectrum of activity of VANCOMYCIN

Narrow

8

what is the tissue penetration of vancomycin when given IV?

Wide:Penetrates most tissues

9

Drug that is eliminated unchanged in urine

vancomycin

10

• Rapid IV infusion of vancomycin may cause diffuse blushing called

“Red man syndrome”

11

Cause of “Red man syndrome”

Rapid IV infusion of vancomycin

12

Toxic effects of vancomycin

 Chills
 Fever
 Phlebitis
 Ototoxicity
 Nephrotoxicity

13

 Antimetabolite inhibitor of cytosolic enolpyruvate transferase

fosfomycin

14

Prevents the formation of N- acetylmuramic acid which is essential in peptidoglycan chain formation

fosfomycin

15

fosfomycin Prevents the formation of -------------- which is essential in peptidoglycan chain formation

N- acetylmuramic acid

16

essential in peptidoglycan chain formation

N- acetylmuramic acid

17

In a single dose, drug is less effective than the 7-day course of treatment with fluoroquinolones

fosfomycin

18

Multiple dosing of this drug can result to resistance rapidly

fosfomycin

19

Diarrhea is common with this drug

fosfomycin

20

common toxicity of fosfomycin

diarrhea

21

fosfomycin is synergistic with (2) drugs in specific infections

beta-lactam and quinolones

22

Excreted in the kidney with urinary levels exceeding the minimum inhibitory concentration (MIC) for many urinary tract pathogens

fosfomycin

23

mode of excretion for fosfomycin

kidney

24

Resistance to this drug occurs via decreased intracellular accumulation of the drug

fosfomycin

25

Peptide antibiotic

C. BACITRACIN

26

Interferes with a late stage in cell wall synthesis in gram (+) organisms

C. BACITRACIN

27

Limited to topical use only

C. BACITRACIN

28

toxicity of bacitracin

nephrotoxicity

29

 Antimetabolite

cycloserine

30

Blocks the incorporation of D-Ala into the pentapeptide side chain of the peptidoglycan

cycloserine

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