Para Lec - Hemoflagellates Trypanosoma Flashcards Preview

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Flashcards in Para Lec - Hemoflagellates Trypanosoma Deck (38)
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1

location of trypanosoma brucei during febrile periods

circulating blood
lymph nodes

2

location of trypanosoma brucei during sleepingperiods

CSF

3

lab diagnosis of trypanosoma cruzi

xenodiagnosis
demonstratoon of trypomastigote in thin and thick smears

4

habitat of t.cruzi

RES, Cardiac muscle, CNS

5

Location of amastigote

1. Amastigote – intracellular (spleen, reticuloendothelial cells, tissues, monocytes)

6

Location of epimastigote

vector?

7

Location of promastigote

develop in gut of vector

8

Location of trypomastigote

final host, in blood circulation

9

– infects cattle

Trypanosoma brucei brucei

10

TRANSMISSION (4)
T. b. gambiense/rhodisiense

• Vector: Tse-tse fly (Common MoT)
• Mechanical transmission: blood-sucking insect
• Mother to child transmission
• Blood transfusion
• Accident infection (pricks)

11

what stage of african trypanosomiasis

• Characterized by swelling/ small papule from

Stage 1: Hemolymphatic Stage

12

– swelling of lymph nodes at posterior neck region or at the cervical vertebrae

Winterbottom’s sign

13

what stage of african trypanosomiasis

• Sleeping sickness stage (blood brain barrier is crossed)

Stage 2: Chronic meningoencephalitic

14

what stage of african trypanosomiasis
Signs and symptoms: personality change, mood swings, insomnia, daytime lethargy, environmental withdrawal, secondary infection (E.g. Pneumonia)

Stage 2: Chronic meningoencephalitic

15

• Specimen for african trypanosomiasis diagnosis

: blood, CSF, lymph node aspirate

16

lab diagnosis for african trypanosomiasis
Gold standard

microscopy

17

treatment
first stage, for T. brucei rhodisiense
-urinary tract, allergic reactions (Side effects?)

• Suramin

18

treatment
first stage, for T. brucei gambiense
-side effects more tolerated

Pentamidine

19

- most important prevention and control for african trypanosomiasis

Education and public awareness

20

phase of american trypanosomiasis disease
– free of symptoms

intermediate phase

21

phase of american trypanosomiasis disease
characterized by chagoma (local swelling, observed on site of inoculation) or skin irritation

acute phase

22

phase of american trypanosomiasis disease
enlargement of esophagus

chronic phase

23

phase of american trypanosomiasis disease
lesions on internal organs like heart, PNS, esophagus, colon

chronic phase

24

phase of american trypanosomiasis disease
3 Mega:

severe/chronic phase

25

what organs involved in 3 mega

megaesophagus
megacolon
megacardiomyopathy

26

vectors of american trypanosomiasis

Vectors: Triatoma, Rhodnius, Panstrongylus

27

transmission of american trypanosomiasis

• Vectors: Triatoma, Rhodnius, Panstrongylus (Also known as kissing bug)
• Ingestion of food contaminated with parasites
• Blood transfusion
• Fetal transmission (13% stillborn deaths per year in Brazil)

28

acute phase of american trypanosomiasis begins

1 week after infection

29

unilateral swelling of eyelids

Romana's sign

30

the stage of the parasite recovered in xenodiagnosis

epimastigote or metacyclic trypomastigote

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