SI LEC - Classes of Antibodies Flashcards Preview

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Flashcards in SI LEC - Classes of Antibodies Deck (75)
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1

Most abundant immunoglobin,

IgG

2

% IgG

75-80% of serum Ig

3

S and MW of IgG

7S, MW=150,000

4

Longest half life (23-25 days)

IgG

5

Half life of IgG

23-25 days

6

IgG which cross the placenta

IgG1, IgG3 and IgG4

7

IgG least efficient in crossing the placenta

IgG2

8

IgG most effective complement activator

IgG3:

9

IgG High affinity for FcR on phagocytic cells, good for opsonization

IgG1 and IgG3

10

FUNCTIONS
Provide immunity to the newborn
Fix complement
Coating antigen (opsonization)
Neutralizing toxins and viruses
Participate in agglutination and precipitation

IgG

11

% IgM

5-10%

12

S and MW of IgM

19S, MW= 970,000

13

Shorter life span than IgG (about 10 days)

IgM

14

Pentameric version is secreted, Monomeric on B cell surface

IgM

15

IgM version in secretion

pentamer

16

IgM version in B cell surface

Monomer

17

5 monomeric units are held together by __ chains

J

18

More efficient than IgG in complement activation

IgM

19

Cannot cross the placenta

IgM

20

Antigen-induced conformational changes in IgM
(2)

starfish or planar
staple or crab

21

FUNCTIONS
Complement fixation
Opsonization
Agglutination
Toxin neutralization



IgM

22

*First Ig of primary immune response

IgM

23

IgG increased at what response (primary or secondary)

secondary

24

conc of IgM in primary and secondary response

SAME

25

Long lag phase
Slow exponential increase in antibody
Short lived response

Primary Immune Response

26

Anamnestic response
Short lag phase
Antibody increase is more rapid
Long lived response

Secondary Immune Response

27

% IgA in serum IgG

10-15% of serum IgG

28

S and MW of IgA

7S and MW=160 000

29

Predominant Ig in secretions

IgA

30

IgA Subclass
found in serum, mainly monomeric, polymers possible not common though

IgA1

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