Flashcards in SI LEC - Classes of Antibodies Deck (75)
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1
Most abundant immunoglobin,
IgG
2
% IgG
75-80% of serum Ig
3
S and MW of IgG
7S, MW=150,000
4
Longest half life (23-25 days)
IgG
5
Half life of IgG
23-25 days
6
IgG which cross the placenta
IgG1, IgG3 and IgG4
7
IgG least efficient in crossing the placenta
IgG2
8
IgG most effective complement activator
IgG3:
9
IgG High affinity for FcR on phagocytic cells, good for opsonization
IgG1 and IgG3
10
FUNCTIONS
Provide immunity to the newborn
Fix complement
Coating antigen (opsonization)
Neutralizing toxins and viruses
Participate in agglutination and precipitation
IgG
11
% IgM
5-10%
12
S and MW of IgM
19S, MW= 970,000
13
Shorter life span than IgG (about 10 days)
IgM
14
Pentameric version is secreted, Monomeric on B cell surface
IgM
15
IgM version in secretion
pentamer
16
IgM version in B cell surface
Monomer
17
5 monomeric units are held together by __ chains
J
18
More efficient than IgG in complement activation
IgM
19
Cannot cross the placenta
IgM
20
Antigen-induced conformational changes in IgM
(2)
starfish or planar
staple or crab
21
FUNCTIONS
Complement fixation
Opsonization
Agglutination
Toxin neutralization
IgM
22
*First Ig of primary immune response
IgM
23
IgG increased at what response (primary or secondary)
secondary
24
conc of IgM in primary and secondary response
SAME
25
Long lag phase
Slow exponential increase in antibody
Short lived response
Primary Immune Response
26
Anamnestic response
Short lag phase
Antibody increase is more rapid
Long lived response
Secondary Immune Response
27
% IgA in serum IgG
10-15% of serum IgG
28
S and MW of IgA
7S and MW=160 000
29
Predominant Ig in secretions
IgA
30
