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Flashcards in PHARMACO - Macrolides Deck (93)
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1

 Large cyclic lactone ring structure with attached sugars

 Erythromycin , azithromycin, and clarithromycin

2

 Good oral bioavailability

Erythromycin , azithromycin, and clarithromycin

3

oral bioavailability of Erythromycin , azithromycin, and clarithromycin

good

4

tissue distribution of Erythromycin , azithromycin, and clarithromycin

wide: Distributed to most body tissues

5

macrolide whose Absorption is impeded by food

azithromycin

6

macrolide which is Eliminated slowly in the urine mainly as unchanged drug

azithromycin

7

half-life of azithromycin

2-4 days

8

macrolide whose levels in tissues and phagocytes are higher than in plasma

azithromycin

9

macrolideS whose Elimination of intact drug is rapid

 Erythromycin and clarithromycin

10

mode of excretion of Erythromycin

biliary excretion

11

mode of excretion of Hepatic metabolism and urinary excretion

Clarithromycin

12

half-life of Clarithromycin

2-5 hours

13

half-life of Erythromycin

2-5 hours

14

macrolide used against chlamydia

erythromycn

15

 Preparations erythromycin


Erythromycin stearate
Erythromycin lactobionate
Erythromycin estolate

16

-Best absorbed oral preparation of erythromycin

Erythromycin estolate

17

spectra of activity of azithromycin and clarithromycin

same with erythro but with GREATER activity

18

Mode of resistance of macrolides in gram +

 Efflux pump mechanisms
 Production of methylase that adds methyl group to the ribosomal binding site

19

Mode of resistance of macrolides to enterobacteriaceae

Formation of drug-metabolizing esterases

20

 Cross-resistance between individual macrolides is complete incomplete partial?

complete

21

if a microorganism is resistant to erythromycin, will it also be resistant to clarithromycin or azithromycin

yes because cross-resistance between individual macrolides is complete

22

cross-resistance with other drugs that bind to the same site occur in methylase-producing strains especially Clindamycin and streptogramins, complete incomplete partial?

PARTIAL

23

enzyme found in the liver
needed to metabolize other drugs

cytochrome P450

24

capable of inhibiting cytochrome P450

erythromycin
and clarithyromycin

25

antibiotic not capable of inhibiting cytochrome P450

azithromycin

26

is erytho still commonly used?

not anymore because of azithro and clarithro

27

antibiotic that promotes the effect of other drug because it inhibits Cyt P450

erythromycin
and clarithyromycin

28

drug against
 Gram (+) cocci like pneumococci (not penicillin-resistant S. pneumoniae [PRSP])
 Beta-lactamase-producing staphylococci (not Methicillin-resistant S. aureus [MRSA] strains)

erythromycin

29

drug of choice for the Prophylaxis against and treatment of M. avium complex

clarithromycin

30

Component for drug regimens for ulcers caused by H. pylori

clarithromycin

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