Flashcards in SI LEC - Innate Immunity Part 3 Deck (24):
1
Covered by long membranous extensions
Dendritic cells
2
dendritic cell in
skin/mucous membrane
Langerhans cells:
3
dendritic cell
organs like heart
Interstitial cell:
4
dendritic cell
T lympho areas in secondary lymphoid organs
Interdigitating cell:
5
cytokines are critical for host defense.
inflammatory cytokines
6
ex of inflammatory cytokines
activates macrophage and PMN phagocytosis and killing
TNFa
7
ex of inflammatory cytokines
activates anti-viral mechanisms
IFNab
8
ex of inflammatory cytokines
stimulates inflammation and fever
IL-1
9
Cytokines
- can function in __ or __ manner
autocrine or paracrine
10
bind specific and sometimes shared receptors to recruit various types of immune cells to the site of infection
chemokines
11
-diverse family of chemotactic cytokines, induce directed chemotaxis of cells
all related in amino acid structure
-promiscuous in receptor usage, each can bind more than one receptor
-likewise, receptors are promiscuous
Chemokines
12
certain chemokines induce cell ____ in addition to cell recruitment
activation
13
smallest granulocyte
basophilia
14
protein discovered in drosophilia (fruit fly) (antifungal)
Toll
15
Toll: protein discovered in
drosophilia (fruit fly) (antifungal)
16
TLR for bacterial parasites
TLR 1 and TLR 2
17
TLR for gram negative bacteria and fungi
TLR 2 and TLR 6
18
TLR for gram +
TLR 4
19
TLR for flagellated
TLR 5&7
20
TLR for viral dsRNA
TLR 3
21
TLR for viral ssRNA
TLR 3& 7
22
Bacterial DNA elements
TLR9
23
what TLRs: Lysosomal localization / what TLRs are subcellular
TLR-3 and TLR7-9
24