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Flashcards in pharmaco - chapter 7 - final Deck (3):
1


 Mimic acetylcholine

CHOLINOMIMETIC DRUGS

2

 Permanently charged quaternary NH4 group
 Relatively insoluble in lipids
 Poorly absorbed
 Poorly distributed in the CNS
 Hydrophilic
 Hydrolyzed in the GIT
 Differ markedly in their susceptibility to hydrolysis by cholinesterase

choline esters

3

type of choline ester

 Very rapidly hydrolyzed
 Large amounts must be infused IV to achieve concentrations high enough to produce detectable effects


ACETYLCHOLINE

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