SI LAB - Glossary 1

Question 1

removal of antibodies from serum by addition of red cells that possess the corresponding surface antigen

Answer 1

absorption

Question 2

antigen that is not genetically determined and is sometimes transient

Answer 2

acquired antigen

Question 3

immunity generated by actual production of antibody by the host in the presence of foreign antigen

Answer 3

active immunity

Question 4

normal serum constituents that increase in the presence of infection, injury, trauma to tissues

Answer 4

acute phase proteins

Question 5

a substance that can increase the specific antibody production to, or the degree of sensitization against antigen by increasing its size or length of survival in the circulation

Answer 5

adjuvent

Question 6

a substance (usually injected with an antigen) that improves the immune response, either humoral or cellular, to the antigen

Answer 6

adjuvent

Question 7

attachment of one substance to the surface of another, in particular, attachment of antibody to specific receptors on a cell surface

Answer 7

adsorption

Question 8

collection into clumps of the cells or particles distributed in a fluid

Answer 8

agglutination

Question 9

antibody capable of causing agglutination with surface antigens

Answer 9

agglutinin

Question 10

an antigen agglutinated or clumped by an agglutinin

Answer 10

agglutinogen

Question 11

system for activating complement beginning at C3 and do not involve a serologic reaction

Answer 11

alternative complement pathway

Question 12

substance in the blood and the lymph serving as one of the active component on the process of cytolysis, the other components being the complement and the cells with antibodies

Answer 12

amboceptor

Question 13

anti-sheep red blood cell antibody that causes hemolysis of sheep red cells in the presence of complement

Answer 13

amboceptor

Question 14

globulin formed in response to exposure to an antigen

Answer 14

antibody (Ab)

Question 15

also known as immunoglobulin

Answer 15

antibody (Ab)

Question 16

any substance that oppose or counteract the action of a complement

Answer 16

Anticomplementary susbtance

Question 17

any substance which, when introduced into the body, stimulates the formation of antibody

Answer 17

Antigen (Ag)

Question 18

union of antibody with its homologous antigen

Answer 18

Antigen-antibody complex

Question 19

an autoantibody directed against a component of the nucleus, commonly found in systemic lupus erythematosus (SLE)

Answer 19

Antinuclear antibody (ANA)

Question 20

serum containing antibody

Answer 20

antiserum

Question 21

an antibody produced against streptolysin O,

Answer 21

antistreptolysin O

Question 22

a hemolysin produced by Group A streptococci

Answer 22

antistreptolysin O

Question 23

ASO meaning

Answer 23

antistreptolysin O

Question 24

antibody produced against self antigen

Answer 24

autoantibody

Question 25

a molecule that behaves as a self antigen

Answer 25

autoantigen

Question 26

lymphocyte from the bursa of Fabricius or an immunoglobulin-forming cell

Answer 26

B-cell

Question 27

substance contained in beef erythrocytes, which is capable of absorbing the heterophil antibodies produced as a result of infectious mononucleosis (IM) and serum sickness

Answer 27

Beef erythrocyte (BE) antigen

Question 28

BE meaning

Answer 28

Beef erythrocyte

Question 29

a protein, not normally present in human blood, appears in a wide variety of inflammatory conditions

Answer 29

C-reactive protein

Question 30

characterized by their ability to react with the C-polysaccharide somatic substance of the pneumococci

Answer 30

C-reactive protein

Question 31

the major system of complement activation that involves all nine components of complement and is initiated by a serologic reaction

Answer 31

Classic complement pathway

Question 32

an agglutinin or hemagglutinin that is active at 4C but not at 37C

Answer 32

Cold agglutinin

Question 33

a humoral mechanism of nonspecific immune response consisting at least 14 components that proceed in a cascading sequence of activation resulting in a cell lysis

Answer 33

Complement

Question 34

fixation of binding of complement in a reaction with antigen and antibody

Answer 34

Complement Fixation

Question 35

monitors day to day accurate performance of the laboratory tests/analyses

Answer 35

Control

Question 36

a substance composed of extract from fresh beef hearts combined with lecithin and cholesterol

Answer 36

Cardiolipin Antigen

Question 37

a hemagglutination test that defines the characteristics of heterophil antibody by guinea pig and beef cell antigens

Answer 37

Davidsohn Differential Test

Question 38

most common procedure for the separation of mononuclear cells

Answer 38

Density gradient centrifugation

Question 39

separation of one substance from the other

Answer 39

dissociation

Question 40

a fluid medium containing antibodies deliberately removed from the red cells

Answer 40

eluate

Question 41

ligand assay in which the label is an enzyme and the binding reagent is an antibody

Answer 41

enzyme immunoassay

Question 42

point of dilution in a serologic reaction in which all the antigen and all the antibody are mutually involved in complexes

Answer 42

equivalence point

Question 43

a specific type of precipitation that occurs over a narrow range of antigen concentration

Answer 43

flocculation

Question 44

aggregation of colloidal particles in a serologic reaction

Answer 44

flocculation

Question 45

heterophil antibody that is stimulated by one antigen and reacts with unrelated surface antigen present on cells from different mammalian species

Answer 45

forssman antibody

Question 46

substance which absorbs the Forssman and serum sickness antibodies

Answer 46

Guinea pig kidney (GPK) antigen

Question 47

flagellar antigens of bacteria

Answer 47

H antigens

Question 48

agglutination or clumping of red blood cells by the antiserum

Answer 48

hemagglutination

Question 49

attachment of antibody to specific receptors on a cell surface

Answer 49

adsorption

Question 50

ANA meaning

Answer 50

antinuclear antibody