BB LAB - Glossary II

Question 1

fusion of malignant and normal cell that produces large quantities of monoclonal antibodies

Answer 1

murine hybridoma

Question 2

group of sugars found on rbc membrane attached to a protein backbone

Answer 2

NANA (Sialic acid)

Question 3

major source of membrane’s net negative charge

Answer 3

NANA (Sialic acid)

Question 4

relating to birth

Answer 4

natal

Question 5

before birth

Answer 5

prenatal

Question 6

after birth

Answer 6

postnatal

Question 7

newborn infant up to 4 months of age

Answer 7

neonate

Question 8

enzyme that cleaves sialic acid from rbc membrane

Answer 8

neuraminidase

Question 9

also known as agglutination-inhibition

Answer 9

Neutralization

Question 10

refers to absence of agglutination due to inability of an Ab to react with red cell antigen because of previously bound soluble substance

Answer 10

Neutralization

Question 11

principle involved in saliva testing

Answer 11

Neutralization

Question 12

basic building blocks of DNA composed of phosphate group, sugar group and base

Answer 12

nucleotide

Question 13

any individual who fails to express any antigens on red cells

Answer 13

null phenotype

Question 14

chemical compound formed by a small number of simple carbohydrate molecules

Answer 14

oligosaccharide chain

Question 15

required temp in C by which the antibody is most reactive

Answer 15

optimum temperature

Question 16

temp for IgM cold reactive antibody

Answer 16

1-6C/20-24C

Question 17

IgG warm reacting antibody

Answer 17

37C

Question 18

spontaneous clumping of rbc against a given serum

Answer 18

panagglutination

Question 19

group O rgt RBC used for Ab ientification

Answer 19

panel cell

Question 20

refers to a woman who had at least one pregnancy

Answer 20

primiparous

Question 21

type of cold autoimmune hemolytic anemia in w/c a biphasic IgG Ab can be demostrated with anti-P specificity

Answer 21

Paroxysmal cold hemoglobinuria

Question 22

D antigen thatis missing part of its typical antigenic structure

Answer 22

Partial D

Question 23

refers to the chance that the alleged father is the biological father

Answer 23

Paternity index

Question 24

diagrammatic chart for illustrating inheritance patterns of traits in a family study

Answer 24

Pedigree chart

Question 25

detectable characteristics of genes

Answer 25

phenotype

Question 26

initial treatment of elevated bilirubin using lights

Answer 26

phototherapy

Question 27

extra blood sample collected during whole blood donation from a donor w/c is intended for serological test

Answer 27

pilot tube

Question 28

fibrinogen containing liquid portion of anticoagulated blood

Answer 28

plasma

Question 29

can be used as specimen for backward typing to detect antibodies however might present problem because it can bring about rouleaux formation

Answer 29

plasma

Question 30

plasma prepared from whole blood subjected to heavy spin wc allow sedimentation of PLT leaving a plasma almost free of PLT

Answer 30

platelet poor plasma

Question 31

plasma prepared from whole blood subjected to SOFT spin wc allow sedimentation of PLT leaving a plasma with high number of PLT

Answer 31

platelet rich plasma

Question 32

products that are transfused in patients suffering from hypovolemia (dec plasma volume) or indicated among burn and shock patients

Answer 32

plasma volume expander

Question 33

NSA meaning

Answer 33

normal serum albumin

Question 34

PPF meaning

Answer 34

plasma protein fraction

Question 35

NSA alb and globulin %

Answer 35

96% Alb + 4% Globulin

Question 36

PPF alb and globulin %

Answer 36

83% Alb + 17% Globulin

Question 37

Synthetic volume expanders

Answer 37

Crystalloids and Colloids

Question 38

plasma derived volume expanders

Answer 38

NSA and PPF

Question 39

Crystalloids [2]

Answer 39

Ringer's Lactate (Na, Cl, K, Ca, lactate ions) | Normal Saline Solution (0.85%-0.9% NaCl)

Question 40

Colloids [2]

Answer 40

Dextran (6%-10%) | HES (Hydroethyl starch)

Question 41

inability of patient to respond favorably after PLT transfusion thus desired increment in PLT not achieved

Answer 41

PLT Refractoriness

Question 42

spontaneous agglutination of red cells by most normal adult sera regardless of blood group

Answer 42

polyagglutination

Question 43

blood group system showing several allelic forms therefore rendering more than one alternative phenotype

Answer 43

polymorphism

Question 44

refers to after child birth

Answer 44

postpartum

Question 45

refers to after tranfusion

Answer 45

posttransfusion

Question 46

relative strength of Ab present in given antiserum usually expressed in titer

Answer 46

potency

Question 47

any substance that enhances Ag-Ab interaction from a given cell-serum mixture w/c may be used to detect low-titered Ab in routine testing

Answer 47

potentiator

Question 48

0.2% in NaCl in glycine

Answer 48

LISS (Low Ionic Strength Saline Solution)

Question 49

this medium has lower ionic strength that increases rate of antibody association incubation may be shortened to 5-15 min if this medium is used

Answer 49

LISS (Low Ionic Strength Saline Solution)

Question 50

positively charge polymer that reduces zeta potential by neutralizing the negative charge in red cell

Answer 50

polybrene

Question 51

useful in identification of Ab in Kidd blood group system

Answer 51

polybrene

Question 52

enhances Ab-Ag rxn by concentrating Ab in the mixture through water removal

Answer 52

Polyethylene glycol

Question 53

PEG meaning

Answer 53

Polyethylene Glycol

Question 54

refers to 2x2 grid used for gene combination

Answer 54

punnett square

Question 55

system of procedures that ensures a lab to operate with most minimal errors

Answer 55

quality assurance

Question 56

close monitoring of lab operations to allow maximum reliability of test result

Answer 56

quality control

Question 57

in transfusion medicine, this refers to a person who benefits and receives blood transfusion

Answer 57

recipient

Question 58

refers to the required speed in a given time to sediment particles from a fluid mixture

Answer 58

relative centrifugal force

Question 59

RCF value

Answer 59

1.118 x 10^5 x radius x (rpm)^2

Question 60

RCF meaning

Answer 60

Relative centrifugal force