Flashcards in BB Lec - Current Trends Deck (54)
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1
Creating RBCs in the laboratory
(blood pharming)
2
mechanism for forming O-type RBCs
The use of enzymes that remove the carbohydrate moieties of the A and B antigens
3
Current research on blood substitutes is focused on two areas:
hemoglobin-based oxygen carriers (HBOCs) and per- fluorocarbons (PFCs)
4
Originally developed to be used in trauma situations such as accidents, combat, and surgery,
RBC substitutes
5
are intimately involved in primary hemostasis,
Platelets
6
interaction of platelets and the vascular endothelium in halting and preventing bleeding following vascular injury.
hemostasis
7
cellular fragments derived from the cytoplasm of megakaryocytes present in the bone marrow.
Platelets
8
They do not contain a nucleus
Platelets
9
platelet DNA found in__
mitochondria
10
average diameter of platelets
2 to 4 μm
11
normal plt count
150,000 to 350,000 per μL
12
how many days do PLT circulate
9-12 days
13
how much plt is sequestered in the microvasculature of the spleen as functional reserves.
30% of the platelets
14
Used to treat bleeding as associated with thrombocytopenia
PLT
15
Efficacy of transfused platelets: estimated from __
CORRECTED COUNT INCREMENT
16
CORRECTED COUNT INCREMENT estimates what of platelets?
Efficacy of transfused platelets:
17
measured after transfusion; does not evaluate or assess the function of the transfused plt
CCI
18
Transfused prophylactically to increase the circulating platelet count in hematology-oncology thrombocytopenic patients to prevent bleeding secondary to drug or radiation therapy
PLT
19
utilized in some instances to treat other disorders in w/c platelets are qualitatively or quantitatively defective because of genetic reasons
PLT
20
MAJOR PROBLEM whenplatelet transfusions were given as freshly drawn whole blood or platelet-rich plasma
circulatory overload
21
Today, platelets are prepared as (2)
concentrates from whole blood
by apheresis
22
The 2007 National Blood Collection and Utilization Survey found that only ??% of platelet doses in the United States were whole blood derived (WBD).
17
23
still remain as the primary means of treating thrombocytopenia
Platelets
24
Storage limit of PLT
5 DAYS
25
The two main reasons for the 5-day shelf-life for platelets are
>bacterial contamination at incubation of 22°C
>loss of platelet quality during storage (known as the platelet storage lesion
26
loss of plt quality and viability
Plt storage lesion:
27
assoc with loss of membrane integrity
Absence of platelet swirling:
28
During the storage of PCs in plasma, the principal buffer is
bicarbonate
29
PLT routinely stored at what temp with continuous agitation (primarily flatbed and circular agitators for up to 5 days).
20°C to 24°C,
30
