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Flashcards in BB Lec - Current Trends Deck (54)
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1

Creating RBCs in the laboratory

(blood pharming)

2

mechanism for forming O-type RBCs

The use of enzymes that remove the carbohydrate moieties of the A and B antigens

3

Current research on blood substitutes is focused on two areas:

hemoglobin-based oxygen carriers (HBOCs) and per- fluorocarbons (PFCs)

4

Originally developed to be used in trauma situations such as accidents, combat, and surgery,

RBC substitutes

5

are intimately involved in primary hemostasis,

Platelets

6

interaction of platelets and the vascular endothelium in halting and preventing bleeding following vascular injury.

hemostasis

7

cellular fragments derived from the cytoplasm of megakaryocytes present in the bone marrow.

Platelets

8

They do not contain a nucleus

Platelets

9

platelet DNA found in__

mitochondria

10

average diameter of platelets

2 to 4 μm

11

normal plt count

150,000 to 350,000 per μL

12

how many days do PLT circulate

9-12 days

13

how much plt is sequestered in the microvasculature of the spleen as functional reserves.

30% of the platelets

14

Used to treat bleeding as associated with thrombocytopenia

PLT

15

Efficacy of transfused platelets: estimated from __

CORRECTED COUNT INCREMENT

16

CORRECTED COUNT INCREMENT estimates what of platelets?

Efficacy of transfused platelets:

17

measured after transfusion; does not evaluate or assess the function of the transfused plt

CCI

18

Transfused prophylactically to increase the circulating platelet count in hematology-oncology thrombocytopenic patients to prevent bleeding secondary to drug or radiation therapy

PLT

19

utilized in some instances to treat other disorders in w/c platelets are qualitatively or quantitatively defective because of genetic reasons

PLT

20

MAJOR PROBLEM whenplatelet transfusions were given as freshly drawn whole blood or platelet-rich plasma

circulatory overload

21

Today, platelets are prepared as (2)

concentrates from whole blood
by apheresis

22

The 2007 National Blood Collection and Utilization Survey found that only ??% of platelet doses in the United States were whole blood derived (WBD).

17

23

still remain as the primary means of treating thrombocytopenia

Platelets

24

Storage limit of PLT

5 DAYS

25

The two main reasons for the 5-day shelf-life for platelets are

>bacterial contamination at incubation of 22°C
>loss of platelet quality during storage (known as the platelet storage lesion

26

loss of plt quality and viability

Plt storage lesion:

27

assoc with loss of membrane integrity

Absence of platelet swirling:

28

During the storage of PCs in plasma, the principal buffer is

bicarbonate

29

PLT routinely stored at what temp with continuous agitation (primarily flatbed and circular agitators for up to 5 days).

20°C to 24°C,

30

In the United States, platelets are being stored WHERE, unless a platelet additive solution is used.

in a 100% plasma medium

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