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Flashcards in connective tissue - histo lec Deck (198)
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1

middle layer of embryo

Mesoderm:

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: embryonic tissue
> stem tissue (point of origin) of all connective tissues

Mesenchyme

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composition of ECM

GROUND SUBSTANCE
FIBERS: elongated polymerized proteins

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colorless and transparent gel-like material

Ground substance

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elongated polymerized proteins
GS component

FIBERS:

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Major component of GS

glycosaminoglycogens (GAGs)

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component of ECM that
3. as lubricant
4. helps prevents invasion of tissues by foreign agents
5. resists forces of compression

ground substance

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composition of GS (3)

glycosaminoglycans, proteoglycans and glycoproteins

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Major GAGs (4)

Chondroitin sulfate, keratan sulfate, heparin sulfate, hyaluronic acid

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made of multiadhesive proteins (fibronectin, integrins,laminin)

GS

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multiadhesive proteins that form the GS
(3)

Fibronectin, integrins,laminin

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FUNCTION OF multiadhesive proteins that form the GS

bind cells to fibers of CT

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multi-adhesive protein of GS
-binding sites: cells, collagen fibers
-connects components of CT, attachment to cells

Fibronectin

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multi-adhesive protein of GS
binding sites for cell membranes
-with collagen and entactinforms basal lamina

Laminin-

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multi-adhesive protein of GS
–integral proteins of plasma membranes
-bind directly to collagen fibers

Integrins

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Three Main Types OF FIBERS

Collagen
Reticular
Elastic

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Types OF FIBERS
>most abundant fibrous protein; large fibers

Collagen

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color of collagen in H&E stain

pink

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color of collagen in Mallory's trichrome

blue

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color of collagen in Masson's stain

green

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type of fiber
great tensile strength (promote flexibility and strength)

collagen

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made up of 3polypeptide chains in helix & cross-linked

tropocollagen

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type of fiber
Not a single entity

collagen

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there are _ types of collagen

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–most common types of collagen; interstitial collagen

type I, type II, type III

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Families of collagen:
a. fibrillar collagen –



e. other collagens –

types I, II, III, V, XI

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Families of collagen:
b. facit collagen –

(fibril-associated collagen with interrupted triple helix) types IX, XII, XIV

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Families of collagen:
c. short-chain collagens –

type VIII, X

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Families of collagen:
d. basement membrane collagen –

type IV

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families of collagen
e. other collagens –

rest of the collagen types

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