Flashcards in connective tissue - histo lec Deck (198)
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middle layer of embryo
Mesoderm:
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: embryonic tissue
> stem tissue (point of origin) of all connective tissues
Mesenchyme
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composition of ECM
GROUND SUBSTANCE
FIBERS: elongated polymerized proteins
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colorless and transparent gel-like material
Ground substance
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elongated polymerized proteins
GS component
FIBERS:
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Major component of GS
glycosaminoglycogens (GAGs)
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component of ECM that
3. as lubricant
4. helps prevents invasion of tissues by foreign agents
5. resists forces of compression
ground substance
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composition of GS (3)
glycosaminoglycans, proteoglycans and glycoproteins
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Major GAGs (4)
Chondroitin sulfate, keratan sulfate, heparin sulfate, hyaluronic acid
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made of multiadhesive proteins (fibronectin, integrins,laminin)
GS
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multiadhesive proteins that form the GS
(3)
Fibronectin, integrins,laminin
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FUNCTION OF multiadhesive proteins that form the GS
bind cells to fibers of CT
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multi-adhesive protein of GS
-binding sites: cells, collagen fibers
-connects components of CT, attachment to cells
Fibronectin
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multi-adhesive protein of GS
binding sites for cell membranes
-with collagen and entactinforms basal lamina
Laminin-
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multi-adhesive protein of GS
–integral proteins of plasma membranes
-bind directly to collagen fibers
Integrins
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Three Main Types OF FIBERS
Collagen
Reticular
Elastic
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Types OF FIBERS
>most abundant fibrous protein; large fibers
Collagen
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color of collagen in H&E stain
pink
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color of collagen in Mallory's trichrome
blue
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color of collagen in Masson's stain
green
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type of fiber
great tensile strength (promote flexibility and strength)
collagen
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made up of 3polypeptide chains in helix & cross-linked
tropocollagen
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type of fiber
Not a single entity
collagen
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there are _ types of collagen
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–most common types of collagen; interstitial collagen
type I, type II, type III
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Families of collagen:
a. fibrillar collagen –
e. other collagens –
types I, II, III, V, XI
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Families of collagen:
b. facit collagen –
(fibril-associated collagen with interrupted triple helix) types IX, XII, XIV
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Families of collagen:
c. short-chain collagens –
type VIII, X
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Families of collagen:
d. basement membrane collagen –
type IV
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