Flashcards in SI Lec - Innate Immunity Deck (57):
1
- includes all parts of the body that help in the recognition and destruction of foreign materials.
Immune System
2
is the body's ability to fight off harmful micro-organisms –PATHOGENS- that invade it.
Immunity
3
2 types of immunity
innate
adaptive
4
____ immunity occurs when when one makes his/her own antibodies. This type of immunity is long term.
Active
5
If you get an infectious disease (like Chicken Pox), often times, that stimulates the production of ____ cells which are then stored to prevent the infection in the future.
MEMORY
6
purely an injection of antibodies to provide temporary immunity.
Gamma Globulin shot
7
-also called innate immunity
Natural Immunity
8
-non specific/non-adaptive immunity
Natural Immunity
9
type of immunity: -same response for all pathogens
Natural Immunity
10
type of immunity
-ability to resist infection by means of normally present body functions
Natural Immunity
11
type of immunity
no prior exposure is required
Natural Immunity
12
type of immunity
response does not change upon repeated exposure
Natural Immunity
13
type of immunity
influenced by factors like nutrients, age, fatigue, stress and genetic determinants
Natural Immunity
14
Natural Immunity influenced by what factors
nutrients, age, fatigue, stress and genetic determinants
15
defense mechanism of natural immunity
keep microorganisms from entering the body
External defense mechanism
16
defense mechanism of natural immunity
involve
both cellular and humoral factors
Internal defense mechanism
17
includes physical, chemical, and cellular barriers
Innate Immune System
18
barrier of
Innate Immune System
eg. skin and mucous membranes
physical
19
barrier of
Innate Immune System
eg. stomach acidity, secreted anti-microbial peptides
chemical barriers
20
barrier of Innate Immune System
eg. macrophages, neutrophils
cellular
21
innate immune response activation occurs within __ (how long) of pathogen recognition
minutes
22
Structural barriers that prevent microorganisms from entering the body
External Defense System
23
External Defense System
components (3)
Intact skin
Mucous membranes
Secretions
24
anti-fungal peptides called (intestinal tract)
alpha-defensins
25
anti-microbial peptides called (respiratory, urogenital tract)
beta-defensins
26
opsonize pathogens for enhanced phagocytosis (lung)
surfactant-A and -D proteins
27
location
lactic acid (2)
sweat
vagina
28
location
fatty acids
sebaceous glands
29
location
- lysozyme
saliva
tears
30
location
acid pH
stomach
31
location
alpha-defensins
intestinal tract
32
location
beta-defensins
RT and urogenital tract
33
location
surfactant-A and -D proteins
lungs
34
Epithelial defense mechanisms (3)
Flushing action of urine (also acid pH)
Motion of the cilia
Presence of normal flora (competitive exclusion)
35
components of internal defense system
Cells and soluble factors
36
what defense system Recognize molecules
internal defense system
37
Normal serum constituents
Increase rapidly due to infection, trauma, injury
Acute Phase Reactants
38
Normal serum constituents
enhances phagocytosis
Acute Phase Reactants
39
Acute Phase Reactants produced by
hepatocytes
40
Acute Phase Reactants produced by hepatocytes within __ in response to __
12-24 hours in response to cytokines
41
intracellular signaling polypeptide; produced mainly by macrophages at the sites of inflammation
Cytokine
42
Cytokine- intracellular signaling polypeptide; produced mainly by ____
macrophages at the sites of inflammation
43
Trace constituent of serum
Declines rapidly w/ cessation of stimulus
C-Reactive Protein
44
Thought to be an antibody to the c-polysaccharide of pneumococci
C-Reactive Protein
45
increases w/in 4-6 hours following infection, surgery, trauma
C-Reactive Protein
46
Peaks w/in 48 hours
C-Reactive Protein
47
C-Reactive Protein
Peaks w/in ? hours
48
48
C-Reactive Proteinincreases w/in ?? hours following infection, surgery, trauma
4-6
49
= common constituent of microbial membrane
phosphocholine
50
Belongs to the family of pentraxins
CRP
51
Acts like an antibody (primitive ab)
CRP
52
Capable of opsonization, agglutination, precipitation, C’ activation
CRP
53
Ca dependent, non-specific
CRP
54
substrate of CRP
Phosphocholine
55
Half life of CRP
19 hours
56
MW of CRP
= 118000 daltons
57