SI Lec - Innate Immunity

Question 1

• includes all parts of the body that help in the recognition and destruction of foreign materials.

Answer 1

Immune System

Question 2

is the body’s ability to fight off harmful micro-organisms –PATHOGENS- that invade it.

Answer 2

Immunity

Question 3

2 types of immunity

Answer 3

innate

adaptive

Question 4

____ immunity occurs when when one makes his/her own antibodies. This type of immunity is long term.

Answer 4

Active

Question 5

If you get an infectious disease (like Chicken Pox), often times, that stimulates the production of ____ cells which are then stored to prevent the infection in the future.

Answer 5

MEMORY

Question 6

purely an injection of antibodies to provide temporary immunity.

Answer 6

Gamma Globulin shot

Question 7

-also called innate immunity

Answer 7

Natural Immunity

Question 8

-non specific/non-adaptive immunity

Answer 8

Natural Immunity

Question 9

type of immunity: -same response for all pathogens

Answer 9

Natural Immunity

Question 10

type of immunity

-ability to resist infection by means of normally present body functions

Answer 10

Natural Immunity

Question 11

type of immunity

no prior exposure is required

Answer 11

Natural Immunity

Question 12

type of immunity

response does not change upon repeated exposure

Answer 12

Natural Immunity

Question 13

type of immunity

influenced by factors like nutrients, age, fatigue, stress and genetic determinants

Answer 13

Natural Immunity

Question 14

Natural Immunity influenced by what factors

Answer 14

nutrients, age, fatigue, stress and genetic determinants

Question 15

defense mechanism of natural immunity

keep microorganisms from entering the body

Answer 15

External defense mechanism

Question 16

defense mechanism of natural immunity

involve
both cellular and humoral factors

Answer 16

Internal defense mechanism

Question 17

includes physical, chemical, and cellular barriers

Answer 17

Innate Immune System

Question 18

barrier of
Innate Immune System
eg. skin and mucous membranes

Answer 18

physical

Question 19

barrier of
Innate Immune System
eg. stomach acidity, secreted anti-microbial peptides

Answer 19

chemical barriers

Question 20

barrier of Innate Immune System

eg. macrophages, neutrophils

Answer 20

cellular

Question 21

innate immune response activation occurs within __ (how long) of pathogen recognition

Answer 21

minutes

Question 22

Structural barriers that prevent microorganisms from entering the body

Answer 22

External Defense System

Question 23

External Defense System

components (3)

Answer 23

Intact skin
Mucous membranes
Secretions

Question 24

anti-fungal peptides called (intestinal tract)

Answer 24

alpha-defensins

Question 25

anti-microbial peptides called (respiratory, urogenital tract)

Answer 25

beta-defensins

Question 26

opsonize pathogens for enhanced phagocytosis (lung)

Answer 26

surfactant-A and -D proteins

Question 27

``` location lactic acid (2) ```

Answer 27

sweat | vagina

Question 28

location | fatty acids

Answer 28

sebaceous glands

Question 29

location | - lysozyme

Answer 29

saliva | tears

Question 30

location | acid pH

Answer 30

stomach

Question 31

location | alpha-defensins

Answer 31

intestinal tract

Question 32

location | beta-defensins

Answer 32

RT and urogenital tract

Question 33

location | surfactant-A and -D proteins

Answer 33

lungs

Question 34

Epithelial defense mechanisms (3)

Answer 34

Flushing action of urine (also acid pH) Motion of the cilia Presence of normal flora (competitive exclusion)

Question 35

components of internal defense system

Answer 35

Cells and soluble factors

Question 36

what defense system Recognize molecules

Answer 36

internal defense system

Question 37

Normal serum constituents | Increase rapidly due to infection, trauma, injury

Answer 37

Acute Phase Reactants

Question 38

Normal serum constituents | enhances phagocytosis

Answer 38

Acute Phase Reactants

Question 39

Acute Phase Reactants produced by

Answer 39

hepatocytes

Question 40

Acute Phase Reactants produced by hepatocytes within __ in response to __

Answer 40

12-24 hours in response to cytokines

Question 41

intracellular signaling polypeptide; produced mainly by macrophages at the sites of inflammation

Answer 41

Cytokine

Question 42

Cytokine- intracellular signaling polypeptide; produced mainly by ____

Answer 42

macrophages at the sites of inflammation

Question 43

Trace constituent of serum Declines rapidly w/ cessation of stimulus

Answer 43

C-Reactive Protein

Question 44

Thought to be an antibody to the c-polysaccharide of pneumococci

Answer 44

C-Reactive Protein

Question 45

increases w/in 4-6 hours following infection, surgery, trauma

Answer 45

C-Reactive Protein

Question 46

Peaks w/in 48 hours

Answer 46

C-Reactive Protein

Question 47

C-Reactive Protein | Peaks w/in ? hours

Answer 47

48

Question 48

C-Reactive Proteinincreases w/in ?? hours following infection, surgery, trauma

Answer 48

4-6

Question 49

= common constituent of microbial membrane

Answer 49

phosphocholine

Question 50

Belongs to the family of pentraxins

Answer 50

CRP

Question 51

Acts like an antibody (primitive ab)

Answer 51

CRP

Question 52

Capable of opsonization, agglutination, precipitation, C’ activation

Answer 52

CRP

Question 53

Ca dependent, non-specific

Answer 53

CRP

Question 54

substrate of CRP

Answer 54

Phosphocholine

Question 55

Half life of CRP

Answer 55

19 hours

Question 56

MW of CRP

Answer 56

= 118000 daltons

Question 57

Uses of CRP

Answer 57

Indicator of acute inflammation Non-specific indicator of disease or trauma Following course of malignancy and organ transplantat