BB Lec - RBC Biology and Preservation Flashcards Preview

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Flashcards in BB Lec - RBC Biology and Preservation Deck (68)
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1

two important RBC characteristics:

deformability and permeability

2

is the network of proteins that contributes shape, strength, and function to a cell membrane.

cytoskeleton

3

gives RBC their characteristic biconcave shape

cytoskeleton

4

purpose of biconcave shape of RBCs

to allow gas exchange while carrying great quantities of oxygen

5

gives a red cell flexibility
strengthens the cell membrane,
facilitates its efficient travel through capillaries

Cytoskeleton

6

CAUSES OF SPHEROCYTOSIS (4)

defects in:
spectrin
spectrin and ankyrin
anion exchanger
palidin

7

defect in proteins that provides vertical support


HEREDITARY SPHEROCYTOSIS

8

defect in proteins that provide horizontal support

HEREDITARY ELLIPTOCYTOSIS:

9

causes of loss of deformability (2)

The loss of adenosine triphosphate (ATP) (energy) levels [leads to a decrease in the phosphorylation of spectrin and, in turn, a loss of membrane deformability]

An accumulation or increase in deposition of membrane calcium also results, [causing an increase in membrane rigidity and loss of pliability ]

10

loss of ATP leads to ___

decrease in the phosphorylation of spectrin

11

decrease in the phosphorylation of spectrin leads to

loss of membrane deformability

12

manifestations of loss of membrane deformability [3]

spherocytes
bite cells
shortened lifespan

13

cells with a reduced surface-to-volume ratio and in which the

“spherocytes”

14

what cells
removal of a portion of membrane has left a permanent indentation in the remaining cell membrane

“bite cells"

15

The RBC membrane is freely permeable to

water and anions

16

importance of permeability of rbc membrane (2)

prevent colloid hemolysis
control the volume of the RBC

17

responsible for 90% of ATP generation



EMP

18

processes/reactions in stage 1 emp

phosphorylation, isomerization, diphosphorylation

19

end product of emp

end product: 3GP

20

3rd stage of emp, product:

pyruvate

21

Produces (reduced) NADPH and reduced glutathione

HMP

22

prevents iron of Hgb from being oxidized (maintains ferrous state)

Methemoglobin reductase pathway

23

2,3 DPG generation

RLP

24

What form
B chains are closer together

Relaxed form

25

What form
B chains are farther

Tensed form

26

Is the effect pH has on HGB-oxygen affinity

HGB-DISSOCIATION CURVE

27

Increase pH is a shift to ?? (inc or dec HGB affinity for O2)

left
increased HGB affinity for O2

28

example of shift to left

hyperventilation

29

Decrease pH --> shift to ??( increased or decreased HGB affinity for O2)

right
decreased HGB affinity for O2

30

example of shift to right

EXERCISE
RENAL FAILURE

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