Flashcards in GPHT LEC - Inflammation Deck (75)
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1
A complex reaction to various injurious agents
Inflammation
2
Consists of vascular responses, migration and activation of leukocytes, and systemic reactions
Inflammation
3
Unique features of inflammation
◦ Reaction of blood vessels
◦ Accumulation of fluids and electrolytes in extravascular space
4
components of inflammatory response
vascular and cellular rxn
5
vascular rxn composed of
vasodilation
increased permeability
6
cellular rxn composed of
Margination
Rolling
Adhesion
Transmigration
Migration
7
Inflammation is terminated when
the inciting agent is eliminated and the mediators have degenerated.
8
A rapid response to an injurious agent that aims to rapidly bring mediators of inflammation to the site of injury
acute inflammation
9
characteristics of acute inflammation
◦ Alterations in blood flow
◦ Increased vascular permeability
◦ Emigration,accumulation,and activation of neutrophils
10
distinctive feature of acute inflammation
Infiltration by polymorphonuclear cells (neutrophils, eosinophils, basophils)
11
Hallmark of acute inflammation:
◦ Increased vascular
permeability
12
Refers to an excess fluid in the interstitial tissue or serous cavities
edema
13
The escape of fluid, proteins, and blood cells from the vascular system into interstitial tissue or body cavities
Two types
◦ ◦
Exudate Transudate
exudation
14
two types of exudate
high cellularity, sp gr and protein
exudate
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two types of exudate
low to none cellularity, sp gr and protein
transudate
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An exudate rich in inflammatory cells (leukocytes) and cellular debris
pus
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morphologic patterns of acute inflammation
◦ Plasma-like effusion with no cells
Serous
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morphologic patterns of acute inflammation
◦ There is abundant protein- rich fluid exudate with a relatively low cellular content
Serous
19
morphologic patterns of acute inflammation
◦ Early inflammation,heart failure, pleural effusions
Serous
20
morphologic patterns of acute inflammation
◦ Inflammation of the serous
cavities, such as peritonitis, and inflammation of a synovial joint, acute synovitis
Serous
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morphologic patterns of acute inflammation
◦ Vascular dilatation may be apparent to the naked eye
Serous
22
morphologic patterns of acute inflammation
◦ Contains dying and degenerate neutrophils,proteins,tissue debris, infecting organisms
Serous
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morphologic patterns of acute inflammation
◦ The pus may become walled-off by granulation tissue or fibrous
tissue to produce an abscess (a localized collection of pus in a tissue)
Serous
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morphologic patterns of acute inflammation
◦ Caused by pyogenic bacteria
Serous
25
(a localized collection of pus in a tissue)
abscess
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If a hollow viscus fills with pus,this is called an
empyema,
27
accumulation of fluid in body cavities
effusion
28
morphologic patterns of acute inflammation
Contains large amounts of fibrinogen
fibrinous
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morphologic patterns of acute inflammation
◦ Forms thick, sticky meshwork that may cause areas to stick
together
fibrinous
30
