Flashcards in GPHT LEC - Inflammation Deck (75)
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1
A complex reaction to various injurious agents
Inflammation
2
Consists of vascular responses, migration and activation of leukocytes, and systemic reactions
Inflammation
3
Unique features of inflammation
◦ Reaction of blood vessels
◦ Accumulation of fluids and electrolytes in extravascular space
4
components of inflammatory response
vascular and cellular rxn
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vascular rxn composed of
vasodilation
increased permeability
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cellular rxn composed of
Margination
Rolling
Adhesion
Transmigration
Migration
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Inflammation is terminated when
the inciting agent is eliminated and the mediators have degenerated.
8
A rapid response to an injurious agent that aims to rapidly bring mediators of inflammation to the site of injury
acute inflammation
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characteristics of acute inflammation
◦ Alterations in blood flow
◦ Increased vascular permeability
◦ Emigration,accumulation,and activation of neutrophils
10
distinctive feature of acute inflammation
Infiltration by polymorphonuclear cells (neutrophils, eosinophils, basophils)
11
Hallmark of acute inflammation:
◦ Increased vascular
permeability
12
Refers to an excess fluid in the interstitial tissue or serous cavities
edema
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The escape of fluid, proteins, and blood cells from the vascular system into interstitial tissue or body cavities
Two types
◦ ◦
Exudate Transudate
exudation
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two types of exudate
high cellularity, sp gr and protein
exudate
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two types of exudate
low to none cellularity, sp gr and protein
transudate
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An exudate rich in inflammatory cells (leukocytes) and cellular debris
pus
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morphologic patterns of acute inflammation
◦ Plasma-like effusion with no cells
Serous
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morphologic patterns of acute inflammation
◦ There is abundant protein- rich fluid exudate with a relatively low cellular content
Serous
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morphologic patterns of acute inflammation
◦ Early inflammation,heart failure, pleural effusions
Serous
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morphologic patterns of acute inflammation
◦ Inflammation of the serous
cavities, such as peritonitis, and inflammation of a synovial joint, acute synovitis
Serous
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morphologic patterns of acute inflammation
◦ Vascular dilatation may be apparent to the naked eye
Serous
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morphologic patterns of acute inflammation
◦ Contains dying and degenerate neutrophils,proteins,tissue debris, infecting organisms
Serous
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morphologic patterns of acute inflammation
◦ The pus may become walled-off by granulation tissue or fibrous
tissue to produce an abscess (a localized collection of pus in a tissue)
Serous
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morphologic patterns of acute inflammation
◦ Caused by pyogenic bacteria
Serous
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(a localized collection of pus in a tissue)
abscess
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If a hollow viscus fills with pus,this is called an
empyema,
27
accumulation of fluid in body cavities
effusion
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morphologic patterns of acute inflammation
Contains large amounts of fibrinogen
fibrinous
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morphologic patterns of acute inflammation
◦ Forms thick, sticky meshwork that may cause areas to stick
together
fibrinous
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