GPHT LEC - Inflammation Flashcards Preview

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Flashcards in GPHT LEC - Inflammation Deck (75)
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1

A complex reaction to various injurious agents

Inflammation

2

 Consists of vascular responses, migration and activation of leukocytes, and systemic reactions

Inflammation

3

Unique features of inflammation

◦ Reaction of blood vessels
◦ Accumulation of fluids and electrolytes in extravascular space

4

components of inflammatory response

vascular and cellular rxn

5

vascular rxn composed of

vasodilation
increased permeability

6

cellular rxn composed of

 Margination
 Rolling
 Adhesion
 Transmigration
 Migration

7

Inflammation is terminated when

the inciting agent is eliminated and the mediators have degenerated.

8

A rapid response to an injurious agent that aims to rapidly bring mediators of inflammation to the site of injury

acute inflammation

9

characteristics of acute inflammation

◦ Alterations in blood flow
◦ Increased vascular permeability
◦ Emigration,accumulation,and activation of neutrophils

10

distinctive feature of acute inflammation

Infiltration by polymorphonuclear cells (neutrophils, eosinophils, basophils)

11

Hallmark of acute inflammation:

◦ Increased vascular
permeability

12

Refers to an excess fluid in the interstitial tissue or serous cavities

edema

13


The escape of fluid, proteins, and blood cells from the vascular system into interstitial tissue or body cavities
Two types
◦ ◦
 
Exudate Transudate

exudation

14

two types of exudate
high cellularity, sp gr and protein

exudate

15

two types of exudate
low to none cellularity, sp gr and protein

transudate

16

An exudate rich in inflammatory cells (leukocytes) and cellular debris

pus

17

morphologic patterns of acute inflammation

◦ Plasma-like effusion with no cells


Serous

18

morphologic patterns of acute inflammation
◦ There is abundant protein- rich fluid exudate with a relatively low cellular content

Serous

19

morphologic patterns of acute inflammation
◦ Early inflammation,heart failure, pleural effusions

Serous

20

morphologic patterns of acute inflammation
◦ Inflammation of the serous
cavities, such as peritonitis, and inflammation of a synovial joint, acute synovitis


Serous

21

morphologic patterns of acute inflammation
◦ Vascular dilatation may be apparent to the naked eye

Serous

22

morphologic patterns of acute inflammation
◦ Contains dying and degenerate neutrophils,proteins,tissue debris, infecting organisms

Serous

23

morphologic patterns of acute inflammation
◦ The pus may become walled-off by granulation tissue or fibrous
tissue to produce an abscess (a localized collection of pus in a tissue)

Serous

24

morphologic patterns of acute inflammation
◦ Caused by pyogenic bacteria

Serous

25

(a localized collection of pus in a tissue)

abscess

26

If a hollow viscus fills with pus,this is called an

empyema,

27

accumulation of fluid in body cavities

effusion

28

morphologic patterns of acute inflammation
Contains large amounts of fibrinogen

fibrinous

29

morphologic patterns of acute inflammation
◦ Forms thick, sticky meshwork that may cause areas to stick
together

fibrinous

30

morphologic patterns of acute inflammation
◦ Often seen in acute pericarditis giving the parietal and visceral
pericardium a 'bread and butter' appearance.

fibrinous

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