SI Lec - Lymphatic System Flashcards by Carmina Mislang

lymphatic system consists of

lymphatic vessels
lymphoid tissues
lymphoid organs

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– activation of immune cells

lymphoid organs

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counterpart of blood vessels; channels for lymph fluid

lymphatic vessels

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results if system blocked or surgically removed

Edema

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Terminal points of veins and arteries

Lymph capillaries

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Have one way minivalves allowing excess fluid to enter but not leave

Lymph capillaries

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Picks up bacteria and viruses as well as proteins, electrolytes and fluid

Lymph capillaries

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Absent from bone, bone marrow, teeth, CNS

Lymph capillaries

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Lymph capillaries are absent from (4)

Bone, BM, CNS, teeth

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Similar to blood vessels (3 layers), but thin & delicate

lymphatic collecting vessels

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Superficial lymphatic collecting vessels in skin travel with ___

superficial veins

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Deep lymphatic collecting vessels of trunk and digestive viscera travel with deep arteries

deep veins

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pressure in lymphatic collecting vessels

very low

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distinctive appearance of lymphatic collecting vessels seen in __

lymphangiography

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Lymphatic collecting vessels

drain into

lymph nodes

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type of lymphoid organ, for production and maturation of lymphocytes

primary lymphoid organs

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type of lymphoid organ, for differentiation and activation of lymphocytes

secondary lymphoid organs

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primary lymphoid organs

Bone Marrow

Thymus

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secondary lymphoid organs

MALT (Mucosa Associated Lymphoid Tissue)
Tonsils
Appendix
CALT (Cutaneous Associated Lymphoid Tissue)

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-standby areas for immunocompetent lymphocytes (waiting for Ag encounter)

secondary lymphoid organs

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Largest tissue of the body

Bone marrow

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Produce all blood cells

Bone marrow

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total weight of BM

1300 - 1500 g (adult)

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Main source of hematopoietic tissue

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Center for Ag-independent lymphopoeisis

Give % of B, T, NK cells in peripheral blood

In peripheral blood , B cells= 20% T cells= 61-89%, NK cells=22%

Where T cells develop their identity

thymus

Small, flat, bilobed organ found in the thorax, right below the thyroid gland and overlying the heart

thymus

mass of thymus at birth

30 g

mass of thymus at puberty

35 g

region of thymus where surface Ags are acquired

CORTEX

region of thymus | where T lympho are released

Medulla

Where reproduction of lymphocytes occur (Ag dependent)

Secondary Lymphoid Organs

Largest secondary lymphoid organ

spleen

length of spleen in cm

weight of adult spleen

150 g

location of spleen

Upper-left quadrant of the abdomen

secondary lymphoid organ for large discriminating filter

spleen

secondary lymphoid organ for Pitting and culling

spleen

splenic tissue can be divided into

red pulp and white pulp

splenic tissue type which | destroys old RBCs; extravascular hemolysis (macrophage-mediated)

red pulp

splenic tissue type which contains the lymphoid tissue; for immunity

white pulp

PALS meaning

Periarteriolar Lymphoid Sheath

PALS contents

T cells

Primary follicles contents:

B cells

Marginal zones contents

dendritic cells (phagocytic or antigen-presenting cells)

eat cells with hidden Ag, unveil the Ag, and present it to lymphocytes.

Dendritic cells

superficial lymph nodes

cervical axillary inguinal

deep lymph nodes

tracheobronchial aortix iliac

drainage of Superior R 1/4 of body

right lymphatic duct

drainage of the rest of the body

thoracic duct

Central collecting points for lymph fluid from adjacent tissues

lymph nodes

main fxn of lymph nodes

Filtration and generation of B memory cells

lymph nodes

contents of cortex of lymph nodes

macrophages, B cells

primary follicle of lymph node cortex contains __

resting B cells

secondary follicle/germinal center of cortex contains __

Ag stimulated B-cells

Paracortex of lymph node contains

T cells, interdigitating cells/Ag-presenting cells

Medulla contains

T cells, B cells, MO, plasma cells

specialized MALT

Peyer’s patches

trap pathogens entering the respiratory and alimentary tracts

tonsils

once believed to be a vestigial organ

appendix

filter bacteria in digestive system

appendix

epidermis + lymphocytes

CALT

potential sites for contact wih Ag

Secondary lymphoid organs:

Aggregated lymphoid nodules

Peyer's patches

contains About 40 follicles, 1 cm wide

peyer's patches

found in the distal small intestine (ileum

peyer's patches

peyer's patches contains how many follicles and their width

About 40 follicles, 1 cm wide

peyer's patches found where

distal S.I. (ileum)