Flashcards in HEMA 2 LEC - Mature Lymphoid Neoplasms 3 Deck (44):
1
• Large atypical cells with pleomorphic nuclei and abundant cytoplasm.
Anaplastic Large Cell Lymphoma
2
• Expression of CD30 antigen and ALK protein
Anaplastic Large Cell Lymphoma
3
• If with fibrosis: anaplastic large cell lymphoma may resemble ____
Hodgkin lymphoma
4
t(2;5)(p23;35) between the ALK and nucleophosmin genes
Anaplastic Large Cell Lymphoma
5
t(2;5)(p23;35)
Anaplastic Large Cell Lymphoma
6
• Pan–T-cell markers (CD3, CD7, CD5): often absent
Anaplastic Large Cell Lymphoma
7
• Proportion of cells are large with abundant cytoplasm and pleomorphic, eccentric, kidney-shaped nuclei, so-called hallmark cells
Anaplastic Large Cell Lymphoma
8
Cells found in Anaplastic Large Cell Lymphoma
large with abundant cytoplasm and pleomorphic, eccentric, kidney-shaped nuclei
Hallmark cells
9
• One of the most common lymphomas in the pediatric population (10% to 15% of childhood lymphomas) disseminated nodal disease with constitutional symptoms
Anaplastic Large Cell Lymphoma
10
most important prognostic feature of Anaplastic Large Cell Lymphoma
expression of ALK protein
11
___disease has a favorable prognosis: ALK+ or ALK-
ALK+
12
___disease shows survival rates more comparable to those for peripheral T-cell lymphoma, unspecified: ALK+ or ALK-
ALK-
13
2 categories of Hodgkin lymphoma
o Nodular lymphocyte-predominant Hodgkin lymphoma
o Classical Hodgkin lymphoma
14
• B-cell neoplasm composed of relatively rare neoplastic cells (lymphocytic/histiocytic or “popcorn” cells) scattered within nodules of reactive lymphocytes
Nodular lymphocyte-predominant Hodgkin lymphoma
15
do cells of Nodular lymphocyte-predominant Hodgkin lymphoma show EBV infection
No
16
• heterogenous group of lymphoid neoplasms derived from the germinal center.
• presence of relatively few diagnostic neoplastic cells, Reed-Sternberg cells, in a rich reactive background
Classical Hodgkin Lymphoma
17
in the United States and Europe, it is a common form of lymphoma occurring in young adults
Classical Hodgkin Lymphoma
18
subtypes of Classical Hodgkin Lymphoma (4)
1. Nodular sclerosis
2. Mixed cellularity
3. Lymphocyte rich
4. Lymphocyte depleted
19
what cells are present in all subtypes of classical Hodgkin lymphoma
reed-sternberg cells
20
large lymphoid cell with a bilobed nucleus or two nuclei with prominent eosinophilic nucleoli and abundant cytoplasm (what cell which is present in classical Hodgkin lymphoma)
reed-sternberg cells
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what cell is pathognmonic for Classical Hodgkin Lymphoma
reed-sternberg cells
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variants of reed-sternberg cells
large mononuclear lymphoid cells with an oval nucleus, thick nuclear membrane, distinct eosinophilic nucleolus, and abundant cytoplasm
Hodgkin cells
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variants of reed-sternberg cells - degenerated or apoptotic cells with a pyknotic nucleus and condensed cytoplasm
Mummified cells
24
variants of reed-sternberg cells - occur predominantly in the nodular sclerosis variant of classical Hodgkin lymphoma and are characterized by a lobated nucleus and artifactual retraction of the cytoplasm secondary to formalin fixation. Because of this artifact, the cells appear to be situated in a clear space
Lacunar cells
25
which category of hodgkin lymphoma show EBV infection
classical hodgkin lymphoma
26
what subtype of classical hodgkin lymphoma
presence of broad collagen bands transecting the lymph node, thickening of the nodal capsule and lacunar cells
Nodular sclerosis classical Hodgkin lymphoma
27
most common of all the subtypes of classical Hodgkin lymphoma, accounting for 70% of cases
Nodular sclerosis classical Hodgkin lymphoma
28
what subtype of classical hodgkin lymphoma
background cellularity includes small lymphocytes, eosinophils, and histiocytes
Nodular sclerosis classical Hodgkin lymphoma
29
what subtype of classical hodgkin lymphoma
• frequency of immunohistochemically demonstrable EBV infection is lowest in this variant
Nodular sclerosis classical Hodgkin lymphoma
30
what subtype of classical hodgkin lymphoma
Reed-Sternberg cells and their variants scattered among the diffuse background proliferation of small lymphocytes, histiocytes, eosinophils, neutrophils, and plasma cells.
Mixed cellularity classical Hodgkin lymphoma
31
what subtype of classical hodgkin lymphoma
Typical Reed-Sternberg cells, mononuclear Hodgkin cells, and mummified cells are seen; however, lacunar cells are absent.
Mixed cellularity classical Hodgkin lymphoma
32
what subtype of classical hodgkin lymphoma
fibrotic bands and capsular thickening are not seen
Mixed cellularity classical Hodgkin lymphoma
33
what subtype of classical hodgkin lymphoma
Scattered mononuclear Hodgkin and Reed-Sternberg cells seen along with a vaguely nodular background of small lymphocytes
Lymphocyte-rich classical Hodgkin lymphoma
34
what subtype of classical hodgkin lymphoma
Nodules represent remnants of mantle zones and residual germinal centers
Lymphocyte-rich classical Hodgkin lymphoma
35
what subtype of classical hodgkin lymphoma
Background cellularity is less heterogeneous
Lymphocyte-rich classical Hodgkin lymphoma
36
what subtype of classical hodgkin lymphoma
Uncommon variant of classical Hodgkin lymphoma
Lymphocyte-depleted classical Hodgkin lymphoma
37
what subtype of classical hodgkin lymphoma
Predominant in immunodeficient patients
Lymphocyte-depleted classical Hodgkin lymphoma
38
what subtype of classical hodgkin lymphoma
Scarcity (paucity) of cells of reactive background
Lymphocyte-depleted classical Hodgkin lymphoma
39
what subtype of classical hodgkin lymphoma
Neoplastic Reed-Sternberg cells and their variants are much more frequent
• Cells show evidence of EBV infection
Lymphocyte-depleted classical Hodgkin lymphoma
40
only subtype of classical Hodgkin lymphoma which occurs in slightly older population (because majority: young adults)
lymphocyte-rich variant
41
only subtype of classical Hodgkin lymphoma which does not involve peripheral lymph node
nodular sclerosis
42
subtype of classical Hodgkin lymphoma which shows mediastinal lymphadenopathy
nodular sclerosis
43
subtype of classical Hodgkin lymphoma which
with the best prognosis
nodular sclerosis
44