Flashcards in HEMA 2 LEC - Mature Lymphoid Neoplasms 3 Deck (44)
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1
• Large atypical cells with pleomorphic nuclei and abundant cytoplasm.
Anaplastic Large Cell Lymphoma
2
• Expression of CD30 antigen and ALK protein
Anaplastic Large Cell Lymphoma
3
• If with fibrosis: anaplastic large cell lymphoma may resemble ____
Hodgkin lymphoma
4
t(2;5)(p23;35) between the ALK and nucleophosmin genes
Anaplastic Large Cell Lymphoma
5
t(2;5)(p23;35)
Anaplastic Large Cell Lymphoma
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• Pan–T-cell markers (CD3, CD7, CD5): often absent
Anaplastic Large Cell Lymphoma
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• Proportion of cells are large with abundant cytoplasm and pleomorphic, eccentric, kidney-shaped nuclei, so-called hallmark cells
Anaplastic Large Cell Lymphoma
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Cells found in Anaplastic Large Cell Lymphoma
large with abundant cytoplasm and pleomorphic, eccentric, kidney-shaped nuclei
Hallmark cells
9
• One of the most common lymphomas in the pediatric population (10% to 15% of childhood lymphomas) disseminated nodal disease with constitutional symptoms
Anaplastic Large Cell Lymphoma
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most important prognostic feature of Anaplastic Large Cell Lymphoma
expression of ALK protein
11
___disease has a favorable prognosis: ALK+ or ALK-
ALK+
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___disease shows survival rates more comparable to those for peripheral T-cell lymphoma, unspecified: ALK+ or ALK-
ALK-
13
2 categories of Hodgkin lymphoma
o Nodular lymphocyte-predominant Hodgkin lymphoma
o Classical Hodgkin lymphoma
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• B-cell neoplasm composed of relatively rare neoplastic cells (lymphocytic/histiocytic or “popcorn” cells) scattered within nodules of reactive lymphocytes
Nodular lymphocyte-predominant Hodgkin lymphoma
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do cells of Nodular lymphocyte-predominant Hodgkin lymphoma show EBV infection
No
16
• heterogenous group of lymphoid neoplasms derived from the germinal center.
• presence of relatively few diagnostic neoplastic cells, Reed-Sternberg cells, in a rich reactive background
Classical Hodgkin Lymphoma
17
in the United States and Europe, it is a common form of lymphoma occurring in young adults
Classical Hodgkin Lymphoma
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subtypes of Classical Hodgkin Lymphoma (4)
1. Nodular sclerosis
2. Mixed cellularity
3. Lymphocyte rich
4. Lymphocyte depleted
19
what cells are present in all subtypes of classical Hodgkin lymphoma
reed-sternberg cells
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large lymphoid cell with a bilobed nucleus or two nuclei with prominent eosinophilic nucleoli and abundant cytoplasm (what cell which is present in classical Hodgkin lymphoma)
reed-sternberg cells
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what cell is pathognmonic for Classical Hodgkin Lymphoma
reed-sternberg cells
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variants of reed-sternberg cells
large mononuclear lymphoid cells with an oval nucleus, thick nuclear membrane, distinct eosinophilic nucleolus, and abundant cytoplasm
Hodgkin cells
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variants of reed-sternberg cells - degenerated or apoptotic cells with a pyknotic nucleus and condensed cytoplasm
Mummified cells
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variants of reed-sternberg cells - occur predominantly in the nodular sclerosis variant of classical Hodgkin lymphoma and are characterized by a lobated nucleus and artifactual retraction of the cytoplasm secondary to formalin fixation. Because of this artifact, the cells appear to be situated in a clear space
Lacunar cells
25
which category of hodgkin lymphoma show EBV infection
classical hodgkin lymphoma
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what subtype of classical hodgkin lymphoma
presence of broad collagen bands transecting the lymph node, thickening of the nodal capsule and lacunar cells
Nodular sclerosis classical Hodgkin lymphoma
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most common of all the subtypes of classical Hodgkin lymphoma, accounting for 70% of cases
Nodular sclerosis classical Hodgkin lymphoma
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what subtype of classical hodgkin lymphoma
background cellularity includes small lymphocytes, eosinophils, and histiocytes
Nodular sclerosis classical Hodgkin lymphoma
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what subtype of classical hodgkin lymphoma
• frequency of immunohistochemically demonstrable EBV infection is lowest in this variant
Nodular sclerosis classical Hodgkin lymphoma
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