SULFONAMIDES, TRIMETHOPRIM, AND FLUOROQUINOLONES Flashcards Preview

Botany > SULFONAMIDES, TRIMETHOPRIM, AND FLUOROQUINOLONES > Flashcards

Flashcards in SULFONAMIDES, TRIMETHOPRIM, AND FLUOROQUINOLONES Deck (9):
1

ANTIFOLATE DRUGS
CLASSIFICATION AND PHARMACOKINETICS

Weakly acidic compounds
Common chemical nucleus resembling p-aminobenzoic acid (PABA)
Modest tissue absorption
Hepatic metabolism

SULFONAMIDES

2

SULFONAMIDES
Classified as
Short-acting
Intermediate-acting (sulfamethosaxole)
Long-acting (sulfadoxine)

(sulfisozaxole)

3

SULFONAMIDES
Classified as
Intermediate-acting

(sulfamethosaxole)

4

SULFONAMIDES
Classified as
Long-acting

(sulfadoxine)

5


High concentration in prostatic and vaginal fluids
Large fractions excreted unchanged in urine
Half-life

TRIMETHOPRIM

6


Bacteriostatic inhibitors of folic acid synthesis
Antimetabolites of PABA
Competitive inhibitors of dihydropteroate synthase

SULFONAMIDES

7


Selective inhibitor of bacterial dihydrofolate reductase
Prevents the formation of active tetrahydro
form of folic acid

TRIMETHOPRIM

8


Combination results to sequential blockade of folate synthesis
Bactericidal against susceptible organisms

TRIMETHOPRIM and SULFAMETHOSAXOLE

9

CLINICAL USES
SULFONAMIDES

Gram (+)
Gram (-) organisms
Chlamydia
Nocardia

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