10.27 Opioids Flashcards
(28 cards)
weak mu agonist
5HT rec inhib
NE reuptake inhib
tramadol
modest mu agonist
Ne reuptake inhib
tapentadol
OCH3 in 3, OH in 6
codeine
OCOCH3 on 3 and 6
heroin
used to treat diarrhea
loperamide
for acute pulmonary edema
morphine
for shivering
meperidine
for cough suppression
codeine
dextromethorphan
for opioid withdrawal
methadone
buprenorphine
for opioid overdose
naloxone
naltrexone
used in obstetrics b/c less resp depression
nalbuphine
slow dissociation from mu receptor, so good for opioid withdraal
buprenorphine
extensive first pass metabolism
morphine
fentanyl
glucuronidation
morphine
hydromorphone
CYP3A4
fentanyl
meperidine
CYP2D6
codeine
hydrolysis
remifentanil
heroin
what can cause seizures
M3G, HM3G, normeperidine
can cause respiratory depression
M6G
codeine converted to morphine via
CYP2D6
opioid MOA
ascending
- presyn: close voltage gated Ca channels, so inhib glutamate and substance P release
- post syn: open K channels so hyperpol
descending
- decrease GABA release, so increase 5HT and NE
only opioid that causes mydriasis instead of miosis
merperidine
all produce bradycardia except
merperidine
what reverses itching caused by opioids
nalbuphine
