Pharm 3

Question 0

Drug that is active and has an active metabolite

Answer 0

Flurazepam (a benzo)

Question 1

2 examples of pro drugs (other than codeine)

Answer 1

Carbamazepine

PPIs

Question 2

Drugs that can be given orally, but usually aren’t

Answer 2

Nitroglycerin (sublingually)

Morphine (IV)

Question 3

Drug that’s never given orally

Answer 3

Fentanyl (opioid)

Question 4

Drugs that are absorbed more in intestine than liver

Answer 4

Chlorpromazine
Cyclosporine
Midazolam

Question 5

Drug that undergoes phase 2 then 1

Answer 5

Isoniazid

Question 6

Example of 2 drugs that bind to same active site on an enzyme

Answer 6

Codeine and paroxetine both bind 2D6

Question 7

What drug era conjugated to sulfate

Answer 7

Acetaminophen

Question 8

Influence of age on metabolism (young and old)

Answer 8

Phase 1 and 2 enzymes increase after birth

Phase 1 decreases in elderly

Question 9

3 common polymorphisms for CYP genes

Answer 9

2C9
2C19
2D6

Question 10

Tamoxifen and CYP polymorphisms

Answer 10

Bad to be 2D6 poor metabolizer

Good to be 2C19 poor metabolizer

Question 11

Dihydropyrimidine dehydrogenase involved in what reaction

Answer 11

Deactivated 5FU

Question 12

N acetyltransferaae acetylates what drugs

Answer 12

Isoniazid
Procainamide
Caffeine

Question 13

UGT metabolizes what drug and polymorphism leads to what?

Answer 13

Irinotecan (prodrug)

Myelosuppression and diarrhea

Question 14

People who suffer respiratory paralysis caused by

Answer 14

Patients deficient in BCHE, which metabolizes succinylcholine (relaxes muscles for endotracheal tubing)