6.30 Clostridium spp

Question 1

tissue death due to reduced blood supply

Answer 1

gangrene

Question 2

primarily due to arterial occlusion, spreads slowly

Answer 2

dry gangrene

Question 3

tissue infected w/ bacteria; can lead to septicemia

Answer 3

wet gangrene

Question 4

gas producing bad infxn, toxin mediated, extreme pain, spreads rapidly

Answer 4

gas gangrene

Question 5

spontaneous GI and gyne infxns

Answer 5

internal gangrene

Question 6

deeper layers of skin

Answer 6

necrotizing fasciitis

Question 7

toxin mediated gangrene

Answer 7

gas gangrene

Question 8

3 types of clostridium

Answer 8

c. perfringens
c. septicum
c. sordelli

Question 9

encapsulated

Answer 9

c. pefringens

Question 10

obligate anaerobe

Answer 10

c. perfringens

Question 11

aerotolerant

Answer 11

c. septicum

Question 12

non motile

Answer 12

c perfringens

Question 13

motile

Answer 13

c. seticum

c. sordelli

Question 14

normal gut flora

Answer 14

c. septicum

Question 15

cause of traumatic gas gangrene

Answer 15

c. perfringens

Question 16

cause of spontaneous gas gangrene

Answer 16

c. septicum

Question 17

TSS

Answer 17

c. sordelli

Question 18

necrotizing soft tissue infections

Answer 18

c. sordelli

Question 19

associated w/ black tar heroin use

Answer 19

c. sordelli

Question 20

cadaveric orthopedic grafts

Answer 20

c. sordelli

Question 21

anaerobic cellulitis

Answer 21

c. perfringens

Question 22

alpha toxin (lecithinase)

Answer 22

c. perfringens

Question 23

alpha toxin (lethal, necrotic)

Answer 23

c. septicum

Question 24

phospholipase C and sphingomyelinase

Answer 24

c. perfringens

Question 25

theta toxin

Answer 25

c. perfringens

Question 26

perfrinogolysin O

Answer 26

c. perfringens

Question 27

pore forming

Answer 27

c. perfringens AND septicum

Question 28

lethal toxin

Answer 28

c. sordelli (septicum's alpha also called lethal)

Question 29

hemorrhagic toxin

Answer 29

c. sordelli

Question 30

glucosylating toxins

Answer 30

c. sordelli

Question 31

100% mortality

Answer 31

c. sordelli

Question 32

67-100% mortality

Answer 32

c. septicum

Question 33

treat with PCN and clindamycin IV

Answer 33

c. perfringens

Question 34

treat w/ high dose IV PCN

Answer 34

c. septicum

Question 35

>25% mortality

Answer 35

c. perfringens

Question 36

maybe can use hyperbaric oxygen

Answer 36

c. perfringens

Question 37

must debride

Answer 37

especially in c. perfringens

Question 38

has a c-terminal domain that can provide protective immunity

Answer 38

c. perfringens

Question 39

foul smelling serosanguinous discharge

Answer 39

c. perfringens

Question 40

no fever

Answer 40

c. sordelli

Question 41

leukemoid reaction (WBC high)

Answer 41

c. sordelli

Question 42

abdominal pain

Answer 42

c. sordelli

Question 43

abdominal distention

Answer 43

c. septicum