10.3 Glial Tumors

Question 1

increased cellularity, astrocytes, mitoses

Answer 1

anaplastic astrocytoma (grade III)

Question 2

ring-like zone of contrast enhancement

Answer 2

glioblastoma

Question 3

vascular endothelial proliferation and necrosis with pseudopalisading

Answer 3

glioblastoma

Question 4

most common glioma in children

Answer 4

pilocytic astrocytoma

Question 5

may be seen in patients w/ neurofibromatosis type 1

Answer 5

pilocytic astrocytoma

Question 6

commonly found below the tentorium

Answer 6

pilocytic astrocytoma

Question 7

visual defects, diabetes insipidus, clumsiness, increased intracranial pressure

Answer 7

pilocytic astrocytoma

Question 8

cystic lesion with contrast enhancing mural nodule

Answer 8

pilocytic astrocytoma

also pleomorphic xanthoastrocytoma

Question 9

contains Rosenthal fibers

Answer 9

pilocytic astrocytoma

Question 10

young patient with long history of seizures

Answer 10

pleomorphic xanthoastrocytoma

Question 11

pleomorphic appearing astrocytes which ares sometimes lipidized

Answer 11

pleomorphic xanthoastrocytoma

Question 12

most people with subependymal giant cell astrocytoma also have

Answer 12

tuberous sclerosis

Question 13

found in lateral ventricles

Answer 13

subependymal giant cell astrocytoma

Question 14

pt with worsening epilepsy or signs of increased intracranial pressure

Answer 14

subependymal giant cell astrocytoma

Question 15

large cells with nucleoli and abundant eosinophilic cytoplasm

Answer 15

subependymal giant cell astrocytoma

Question 16

tuberous sclerosis

• inheritance
• gene mutation
• CNS findings
• other organ findings

Answer 16

autosomal dominant

TSC1 (chromosome 9q) hamartin
TSC2 (chromosome 16p) tuberin

SEGA, cortical tubers, subependymal nodules

cutaneous angiofibromas, renal angiomyolipomas, cardiac rhabdomyomas, pulmonary lymphangioleiomyomatosis

Question 17

round cells with clear halo, anastamosing blood vessels, calcification, microgemistocytes

Answer 17

oligodendroglioma

Question 18

hypointense on T1

hyperintense on T2

Answer 18

diffuse astrocytoma

oligodendroglioma

Question 19

responds to chemotherapy

Answer 19

anaplastic oligodendroglioma

Question 20

loss of chromosomes 1p and 19q

Answer 20

oligodendroglioma

Question 21

loss of what chromosome associated with worse prognosis in oligodendroglioma

Answer 21

9p

Question 22

ependymoma location in kids vs adults

Answer 22

kids - lateral or 4th ventricle

adults - spinal cord

Question 23

ependymal rosettes and canals

Answer 23

ependymoma

Question 24

perivascular pseudorosettes

Answer 24

ependymoma

Question 25

associated with neurofibromatosis 2

Answer 25

ependymoma

Question 26

monosomy 22

Answer 26

ependymoma

Question 27

occurs in filum terminale

Answer 27

myxopapillary ependymoma

Question 28

papillary elements in a myxoid background

Answer 28

myxopapillary ependymoma

Question 29

clumps of ependymal nuclei in a dense fibrillar background

Answer 29

subependymoma

Question 30

choroid plexus papilloma locations children vs adults

Answer 30

children - lateral ventricles adults - 4th ventricle