2.2 Immuno

Question 0

What is MIC?

Answer 0

Something expressed on infected epithelial cells

Question 1

2 receptors that g:d T cells use to bind MICs

Answer 1

TCRg:d

NKG2D

Question 2

CD3-CD56low predominantly in

Answer 2

Blood

Question 3

CD3-CD56high predominantly in

Answer 3

Secondary lymphoid tissues

Question 4

Which NK cell has high cytotoxic capacity

Answer 4

CD3-CD56low

Question 5

What NK cell has high cytokines secretion

Answer 5

CD3-CD56high

Question 6

All NK cells express

Answer 6

CD56

Question 7

NKG2D binds

Answer 7

MIC (infected cell)

Question 8

Inhibitory MHC class I receptors bind

Answer 8

MHC I (healthy cells)

Question 9

What 2 receptors on NK cells bind to what on target/infected cells

Answer 9

NKG2D binds MIC

2B4 binds CD48

Question 10

An alternate way of activating NK cells

Answer 10

NK cell’s FCgRIIIA / CD16 gets bound by IgG attached to Ag on target cell

Question 11

A cell infected by a mycobacterium will express ________ which can be recognized by _______

Answer 11

CD1 a, b, or c

a:b T cell or NK cell

Question 12

NKT cells have a receptor for

Answer 12

CD1d

Question 13

2 signals required for NKT cell activation

Answer 13

a:b TCR bind to CD1d on dendritic cell

IL12 receptor binds IL12 released from dendritic cell

Question 14

Endotoxin tolerance involves

Answer 14

Kupffer cells releasing anti inflammatory IL10 and TGFb for induction of regulatory T cells and activation of NK cells

Question 15

Forward scatter tells you

Answer 15

Cell size

Question 16

Side scatter tells you

Answer 16

Granularity

Question 17

A normal CD4:CD8 ratio is

Answer 17

2

Question 18

Where are CD4 and CD8 on FACS dot plot

Answer 18

CD4 upper left

CD8 lower right

Question 19

An AIDS patient loses which cells

Answer 19

CD4 T cells