Hematologic - cytogenetics Flashcards
(8 cards)
1
Q
t(8;14)
- dx
- type
- age
- protein
- histo
- virus
- CD
A
- Burkitt Lymphoma
- mature B cell lymphoma
- 50-60, kids
- c-MYC
- starry sky
- EBV
- CD10
2
Q
t(11;14)
- dx
- type
- protein
- age
- associated w/ what disease
- CD
A
- Mantle Cell Lymphoma
- mature B cell lymphoma
- cyclin D1
- male 60
- GI tract w/ lymphomatous polyposis
- CD5
3
Q
t(14;18)
- dx
- type
- protein
- histo
- age
- CD
A
- Follicular lymphoma (also Diffuse Large B cell Lymphoma)
- mature B cell lymphoma
- BCL2
- cleaved nucleus / pac man / butt
- females 55, young boys head and neck
- CD10
4
Q
t(2;5)
- dx
- type
- age
- CD & other markers
- histo
A
- Anaplastic Large Cell Lymphoma
- T cell lymphoma
- male under 30
- CD30 (also Hodgkin), ALK-1
- Kidney bean / horseshoe nucleus, wreath cells
5
Q
t(9;22)
- dx
- protein
- type
- age
- problem
A
- Chonic Myelogenous Leukemia (B-ALL)
- BCR/ABL
- Myeloproliferative Disorder
- 40-60
- increase neutrophils
6
Q
t(8;21)
- dx
- type
- age
- histo
- treatment
A
- M2, AML1/ETO
- AML
- younger patients
- granules or Auer rods
- cytarabine
7
Q
inv(16)
- dx
- type
- protein
- treatment
- age
A
- type of M4
- AML
- Smooth Muscle Myosin Heavy Chain
- cytarabine
- all ages, usually younger
8
Q
t(9;11)
- dx
- type
- associated w/
- age
A
- MLL or HRX (type of M5)
- AML
- DIC, skin and gingiva
- children
