Fates of Pyruvate

Question 0

What are the reducing equivalents for glucose in aerobic and anaerobic conditions?

Answer 0

Aerobic: H2O
Anaerobic: lactate

Question 1

Where do the carbons from glucose end up in for aerobic and anaerobic conditions?

Answer 1

Aerobic: CO2
Anaerobic: lactate

Question 2

ATPs made per glucose in aerobic and anaerobic conditions

Answer 2

Aerobic: 30-32
Anaerobic: 2

Question 3

What cells are always in anaerobic conditions?

Answer 3

RBCs (no mito)

White muscle fibers (few mito)

Question 4

2 major uses of lactate

Answer 4

1) conversion of lactate to glucose in liver by glyconeogenesis (requires O2)
2) ATP production (heart) by converting back to pyruvate via LDH reaction then pyruvate oxidation (requires O2)

Question 5

How is lactate cleared from the body?

Answer 5

Kidney excretion

Question 6

What molecularly causes lactic acidosis?

Answer 6

Lactate production up and/or lactate use/clearance down