3.2 micro Flashcards
(28 cards)
Disseminated infection
Bac is in bloodstream so is everywhere
Localized infection
Bac is localized but toxin is everywhere
Intoxication
Ingest toxin, so toxin is the problem
Pathogenicity
Ability to produce disease in host
Ability to produce disease in host
Pathogenicity
Virulence
Degree of pathogenicity
Degree of pathogenicity
Virulence
4 types of virulence factors
Communicability / transmission
Adherence / colonization
Growth / establish disease
Protection against host defense
What bac is very sensitive to drying
Neisseria gonorrhea
What bac dies when exposed to air
Treponema pallidum
What bac is viable in environment for weeks
Staph aureus
What bac is in dried respiratory droplets
Mycobacterium tuberculosis
What virulence factors allow transmission
Persist in environment
Forms spores
What virulence factors help with adherence / colonization
Pili
Motility (flagella, chemotaxis)
Outer membrane proteins
What virulence favors allow growth
Cell wall / Endotoxin
Exotoxins
Intracellular growth
Secretion systems
What virulence factors protect against host defenses
Antigenic variation
Capsule
Biofilm formulation
What can be neutralized by host antibodies
Pili
Omp (outer membrane proteins)
What TLR binds flagellin
TLR5
Example of Endotoxin
LPS
Fever caused by
Low amounts of LPS -> IL1
Vascular leakage / shock caused by
High amounts of LPS -> TNFα
What TLR binds lipoteichoic acid
TLR2
Largest category of bac toxins
AB toxins
3 types of bac entry
Phagocytosis
Zipper type
Macropinocytosis / membrane ruffling
