ETC and Oxidative Phosphorylation Flashcards by Lu Chen

Q

Electrons move spontaneously from

A

Reductants (more neg E) to oxidants (more pos E)

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Q

Define reduction potential (E)

A

Tendency for a compound to gain electrons

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Q

What has low E?

A

Carbs and fats

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Q

What has high E?

A

Oxygen

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Q

Are reductants good or bad electron donors?

A

Good electron donors

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Q

Relationship between ΔE and ΔG

A

ΔG=-nFΔE

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Q

ΔE of a reaction is (equation)

A

E(ox)-E(red)

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Q

Where is the ETC?

A

Inner mitochondrial membrane

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Q

Pumping H+ out generates what kind of potential?

A

Electrical potential

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Q

O2 reduction is done by

A

NADH and FADH2

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Q

Number of H+ pumped out at each complex (1 thru 4)

A

I - 4
II - 0
III - 2
IV - 4

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Q

What are the 2 parts of ATP synthase, and which one is the catalytic subunit?

A

F0, F1 (catalytic subunit)

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Q

Stepwise electron transfer

A

NADH
UQ
Cyt c
O2

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Q

H+ are moved from where to where?

A

Matrix to intermembrane space

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Q

Complex I is also called

A

NADH dehydrogenase

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Q

What are the complex I cofactors?

Study These Flashcards

A

NADH
FMN
Iron sulfur clusters
UQ

Q

NADH

diffusible or enzyme bound?
carries how many electrons?

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A

Diffusible

2 electrons

Q

FMN

diffusible or enzyme bound?
carries how many electrons?

Study These Flashcards

A

Enzyme bound

2 electrons

Q

Iron sulfur clusters

diffusible or enzyme bound?
carries how many electrons?

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A

Enzyme bound

1 electron

Q

UQ

diffusible or enzyme bound?
carries how many electrons?

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A

Diffusible (inner mito membrane)

2 electrons

Q

Overall electron transfer in complex I

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A

From NADH to UQ

Q

Path of electrons in complex I

Study These Flashcards

A

NADH
FMN
(Fe-S)n
UQ

Q

Complex II is also called

Study These Flashcards

A

Succinate-CoQ Reductase

Succinate dehydrogenase in TCA cycle

Q

Electron oath through complex II

Study These Flashcards

A

Succinate
FADH2
2Fe2+
UQH2

Structure of complex II

4 subunits | 2 Fe-S proteins

What is the common electron acceptor?

Ubiquinone (UQ)

Complex III is also called the

Cyt bc1 complex

What does complex III do?

Oxidizes UQH2 to UQ | Reduces Fe3+ to Fe2+ in cytochrome c

Structure of complex III

Dimer

Main transmembrane protein in complex III

Cytochrome b