2.10 immuno

Question 0

Adjuvants act on

Answer 0

APCs, especially dendritic cells

Question 1

What are adjuvants

Answer 1

Substances that enhance immunogenicity of antigens

Question 2

Effects of adjuvants are mediated through activation of

Answer 2

TLRs

Question 3

Mechanism of ISCOMs

Answer 3

ISCOMs enclose a viral peptide
ISCOM fuses with APC (and releases viral peptide inside)
Peptide gets attached to MHC I and activates CD8 T cell

Question 4

Which MHC is strongly associated with resistance to cerebral malaria

Answer 4

HLAB53

Question 5

Peptide vaccine steps for malaria

Answer 5

Identify good candidate peptides (in this case small because it’s an MHCI and pro as second AA)

Test for high binding to HLA(B53) - high binding because it’s a MHCI

Test for proliferation if T cells from infected malaria patients

Question 6

Effects of corticosteroids

Answer 6

Anti inflammatory
Weight gain
Diabetes
Fluid retention
Bone mineral loss
Thinning of skin

Question 7

Therapy for rheumatoid arthritis

Answer 7

Develop a TNFa antibody (so can get rid of immune effects like swelling and inflammation)

Question 8

In RA therapy, what factors are improved

Answer 8

Pain goes down
Less swollen joints
Decr CRP

Question 9

How does anti MHC II antibody therapy work

Answer 9

Normally:
Oligodendrocytes release myelin basic protein (MBP) which the macrophage engulfs
Th1 cells with receptors for MBP bind macrophage and get activated
Th1 cells then activate macrophage to kill oligodendrocytes

If you use anti MHCII Ab, will bind to macrophage so it can’t interact with Th1

If use