6.11 Antipsychotics Flashcards
(25 cards)
Treats tardive dyskinesia
Reserpine or Tetrabenzine to deplete DA
Benzo like clonazepam to increase GABA
Mechanism of typical antipsychotics
Inhibit dopamine D2 receptor
Category that has anti-emetic properties
Typicals
Has anti-emetic action only
Prochlorperazine
Fatal in overdoses
Thioridazine
Doesn’t cross BBB
Prochlorperazine
Used for Tourettes
Haloperidol
Pimozide
More selective D2 antagonist than haloperidol
Pimozide
Used for acute psychosis
Haloperidol
Used for severe childhood ADHD
Haloperidol
Used with the opioid fentanyl for neuroleptic analgesia
Droperidol
Involve QT prolongation
Droperidol
Ziprasidone
Greatest risk of QT prolongation
Ziprasidone
Mechanism of atypicals
D2 receptor inhibitor and also many others such as 5HT, alpha adrenergic, H1
Most weight gain
Clozapine
Olanzapine
Lowest risk for tar dive dyskinesia
Clozapine
D4 receptor antagonist
Clozapine
High dose has the most EPS liability risk of all atypicals
Risperidone
Reduced weight gain
Ziprasidone
Helps w/ depression
Ziprasidone
Used in adjunct w/ antidepressants
Aripiprazole
Partial agonist at D2 and 5HT1A
Antagonist at 5HT2A
Aripiprazole
Used to treat neuroleptic malignant syndrome
Bromocriptine (D2-R antagonist)
Diazepam or Dantrolene (muscle relaxants)
Effects of D1-like receptors
Postsynaptic activation of adenylyl cyclase
