3.8 cancer

Question 0

Lung cancer

Answer 0

Omcogene
Growth factor receptors
EGFR
ALK-EML

Question 1

Breast cancer

Answer 1

Oncogene
Growth factor receptors
Her2neu

DNA repair
Homologous recombination
BRCA1&2

Question 2

Pancreatic cancer

Answer 2

Oncogene
Signal transducing protein
RAS family of GTP-binding proteins

Question 3

Colon cancer

Answer 3

Oncogene
Signal transducing protein
RAS family of GTP-binding proteins

Tumor suppressor
TGFβ

Question 4

CML

Answer 4

Oncogene
Signal transducing protein
c-ABL tyrosine kinase

Question 5

Burkitt lymphoma

Answer 5

Oncogene
Transcription factor
c-MYC

Question 6

Neuroblastoma

Answer 6

Oncogene
Transcription factor
N-MYC

Question 7

Mantle cell lymphoma

Answer 7

Oncogene
Cell cycle regulators
Cyclin D1

Question 8

Retinoblastoma

Answer 8

Tumor suppressor

RB

Question 9

Li-Fraumeni

Answer 9

Tumor suppressor

TP53 (p53 protein)

Question 10

Familial adenomatous polyposis

Answer 10

Tumor suppressor gene

APC

Question 11

Cervical cancer

Answer 11

Tumor suppressor gene

CDKN2A (p16/INK4a & p14ARF)

Question 12

Endometrial cancer

Answer 12

Tumor suppressor

TGFβ

Question 13

Stomach cancer

Answer 13

Tumor suppressor

TGFβ

Question 14

Neurofibromas

Answer 14

Tumor suppressor

NF1 (neurofibromin)

Question 15

Malignant peripheral nerve sheath tumors

Answer 15

Tumor suppressor

NF1 (neurofibromin)

Question 16

Bilateral schwannomas

Answer 16

Tumor suppressor

NF2 (Merlin)

Question 17

Renal cell carcinoma

Answer 17

Tumor suppressor

VHL

Question 18

Pheochromocytoma

Answer 18

Tumor suppressor

VHL

Question 19

Wilms tumor

Answer 19

Tumor suppressor

WT1

Question 20

Basal cell carcinoma (has Gorlin Syndrome)

Answer 20

Tumor suppressor

PTCH1&2 (PATCHED)

Question 21

Medulloblastoma (has Gorlin syndrome)

Answer 21

Tumor suppressor

PTCH1&2 (PATCHED)

Question 22

Follicular cell lymphoma

Answer 22

Anti-apoptosis

BCL2 & BCL-XL

Question 23

Lynch syndrome (Hereditary Non-Polyposis cancer syndrome)

Answer 23

DNA repair
Mutated mismatch repair
MSH2, MLH1, MSH6

Question 24

Xeroderma pigmentosum

Answer 24

DNA repair | Nucleotide excision repair

Question 25

Ataxia telangiectasia

Answer 25

DNA repair | Homologous recombination

Question 26

Bloom's syndrome

Answer 26

DNA repair | Homologous recombination

Question 27

Myeloproliferatve disorders

Answer 27

JAK2

Question 28

Cowden syndrome

Answer 28

Tumor suppressor | PTEN