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From Flashcardlet > 6.19 Bone Drugs > Flashcards

6.19 Bone Drugs Flashcards

(74 cards)

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1
Q

Vitamin D overdose can cause

A

High plasma calcium

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2
Q

Cholestyramine, Colestipol, Mineral oil, Orlistat can inhibit absorption of

A

Vitamin D (b/c it’s a fat soluble vitamin)

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3
Q

Phenytoin and barbiturates can induce enzymes that metabolize

A

Vitamin D (and may lead to Vitamin D deficiency)

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4
Q

Cardiac glycosides have a synergistic reaction with

A 
Vitamin D (both increase calcium)
Human recombinant intact PTH
Teriparatide
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5
Q

Thiazides can interact with

A

Vitamin D

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6
Q

Binds to Vitamin D receptor to activate vitamin D pathways

A

Paricalcitol

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7
Q

Prevent and treat secondary hyperparathyroidism in chronic kidney disease

A

Paricalcitol

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8
Q

Ketoconazole decreases clearance of

A

Paricalcitol

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9
Q

CYP 3A4 inhibitors decrease clearance of

A

Paricalcitol

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10
Q

Molecule that may cause hypercalcemia in certain forms of malignancy

A

PTHrP

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11
Q

Recombinant human PTH

A

Teriparatide

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12
Q

For glucocorticoid induced osteoporosis

A

Human recombinant intact PTH

Teriparatide

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13
Q

For men w/ primary or hypogonadal osteoporosis

A

Human recombinant intact PTH

Teriparatide

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14
Q

Enhances Wnt signaling by inhibiting Sclerostin (a Wnt antagonist)

A

Human recombinant intact PTH

Teriparatide

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15
Q

Can only be used for 2 years

A

Human recombinant intact PTH

Teriparatide

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16
Q

Can cause osteosarcoma

A

Human recombinant intact PTH

Teriparatide

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17
Q

CI if Paget’s disease

A

Human recombinant intact PTH

Teriparatide

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18
Q

CI if osteogenic sarcoma

A

Human recombinant intact PTH

Teriparatide

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19
Q

CI if <18 yo

A

Human recombinant intact PTH

Teriparatide

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20
Q

Bisphosphonates shouldn’t be used with

A

PTH

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21
Q

Can use PTH preps with

A

Reloxifine (SERM)

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22
Q

Prescribed when you want to decrease calcium or phosphate in blood

A

Calcitonin

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23
Q

Treats hypercalcemia, malignancy, osteoporosis

A

Calcitonin

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24
Q

Inhibits osteoclast activity and osteocytic osteolysis

A

Calcitonin

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25
Injections or nasal spray
Calcitonin
26
Rhinitis ADR
Calcitonin
27
Downregulate RANKL and upregulate OPG
Sex steroids (estrogens)
28
Why is estrogen therapy not used
Increase BRCA, heart disease, dementia
29
SERMS
Tamoxifen | Raloxifene
30
Estrogen antagonist on breast and uterus | Estrogen agonist - anabolic on bones and lipids
Raloxifene
31
Reduces incidence of vertebral fractures
Raloxifene
32
Extensive first pass metabolism
Raloxifene
33
ADRs: hot flashes, leg cramps, increase DVT and stroke
Raloxifene
34
Bile acid sequester ants (cholestyramine) reduces absorption of
Raloxifene
35
Raloxifene may decrease absorption of
Levothyroxine (synthroid)
36
What decreases absorption of levothyroxine (synthroid)
Raloxifene
37
Directly incorporated into hydroxyapatite of bone
Bisphosphonates
38
Used for Paget's disease
Bisphosphonates
39
Inhibit osteoclasts
Bisphosphonates
40
Metabolized by osteoclasts to yield ATP
Simple bisphosphonates
41
Not metabolized to analogues of ATP
Nitrogen containing bisphosphonates
42
Inhibits farnesyl pyrophosphate synthase (FPP)
Nitrogen containing bisphosphonates
43
Inhibits bone resorption and mineralization at the same concentration
Etidronate
44
Can inhibit mineralization of bone and cause osteomalacia
Bisphosphonates
45
Bisphosphonate that has low risk of causing osteomalacia
Alendronate
46
IV or oral (on an empty stomach)
Bisphosphonates
47
Can get renal toxicity (acute tubular necrosis)
Bisphosphonates
48
Can cause GI toxicity (oropharyngeal ulcer, esophagitis)
Bisphosphonates
49
Can cause osteonecrosis of the jaw
Bisphosphonates
50
CI in pregnancy
Bisphosphonates
51
CI in upper GI disease
Bisphosphonates
52
CI in osteomalacia
Bisphosphonates
53
IgG mAb to RANKL
Denosumab
54
Preferred therapy for postmenopausal women w/ osteoporosis
Bisphosphonates
55
For postmenopausal women w/ osteoporosis at high risk for fracture
Denosumab
56
For men w/ nonmestatic prostate cancer receiving androgen deprivation therapy
Denosumab
57
For postmenopausal osteopenic women w/ BRCA who are receiving aromatase inhibitors
Denosumab
58
Adults w/ solid tumors and bone mets
Denosumab
59
Need to correct hypocalcemia and it D deficiency before treatment
Denosumab
60
Receive supplemental calcium and vitamin D
Denosumab
61
low dose Teriparatide increases calcium in
bone
62
calcitonin (salmon) increases calcium in
bone
63
sex steroids increase calcium in
bone
64
Raloxifene increases calcium in
bone
65
Bisphosphonates increase calcium in
bone
66
Etidronate increases calcium in
bone
67
Alendronate increases calcium in
bone
68
Denosumab increases calcium in
bone
69
Vitamin D increases calcium in
blood
70
Paricalcitol increases calcium in
blood
71
PTH increases calcium in
blood
72
high dose Teriparatide increases calcium in
blood
73
Thyroid hormones increase calcium in
blood
74
Glucocorticoids increase calcium in
blood

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