Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

From Flashcardlet > 5.12 path lung cancer 5 > Flashcards

5.12 path lung cancer 5 Flashcards

(75 cards)

Start Studying
0
Q

Gefitinib targets

A

Tyrosine kinase domain of EGFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Lung cancer metastasizes to

A

Adrenals
Liver
Brain
Bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Erlotinib targets

A

Tyrosine kinase of EGFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Crizotinib targets

A

ALK

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Bevacizumab targets

A

VEGF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What drug targets the tyrosine kinase domain of EGFR

A

Gefitinib

Erlotinib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What drug targets ALK

A

Crizotinib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What drug targets VEGF

A

Bevacizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

An East Asian female with adenocarcinoma might have what mutation

A

EGFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

EGFR mutation in exons

A

18,19,21

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

KRAS mutations are on exon

A

1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

White smoker with adenocarcinoma most likely has what mutation

A

K-RAS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Young never or ex smoker with adenocarcinoma most likely has what mutation

A

ALK

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Benign mimic of lung cancer

A

Pulmonary hamartoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Epithelial clefts lined by ciliates columnar epithelium

A

Pulmonary hamartoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Nodules of connective tissue intersected by epithelial clefts

A

Pulmonary hamartoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What organ cancers metastasize to the lung

A

Men - lung

Women - lung, breast, ovary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Fibrous pleural plaques

A

Asbestos exposure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Long latency after asbestos exposure

A

Mesothelioma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Bloody pleural effusions encasing lung

A

Mesothelioma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Stubby microvilli on EM

A

Adenocarcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Long slender microvilli on EM

A

Mesothelioma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Mesothelioma can also arise from

A

Peritoneum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Aerogenous spread

A

MUCINOUS adenoma in situ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
One peripheral nodule in lepidic pattern
NON MUCINOUS adenocarcinoma in situ
25
Small lesion with dysplasic pneumocytes lining fibrotic alveolar walls
Atypical adenomatous hyperplasia
26
Peripheral
Adenocarcinoma
27
Glandular or mucin producing
Adenocarcinoma
28
TTF1
Adenocarcinoma
29
More in non or ex smokers
Adenocarcinoma
30
KRAS mutation
Adenocarcinoma
31
EGFR mutation
Adenocarcinoma
32
ALK mutation
Adenocarcinoma
33
Associated with smoking
Squamous cell Small cell Large cell
34
Central
Squamous | Small cell
35
CDKN2A mutation
Squamous cell
36
Tp53 mutation
Squamous cell
37
Amplify FGFR1
Squamous cell
38
May grow into bronchial lumen
Squamous cell
39
Necrosis with cavitation
Squamous
40
Cauliflower like intraparenchymal mass
Squamous
41
Keratin pearls
Squamous
42
Intercellular bridges
Squamous
43
Keratinization
Squamous
44
Diffuse idiopathic pulmonary neuro endocrine cell hyperplasia is the precursor lesion to
Small cell
45
Not surgically curable
Small cell
46
Another name for small cell
Neuroendocrine
47
ACTH
Small cell
48
ADH
Small cell
49
Small blue cells
Small cell
50
Scant cytoplasm
Small cell
51
Salt and pepper nuclear chromatin
Small cell
52
Round, soluble shaped cells with nuclear molding
Small cell
53
High mitotic count
Small cell
54
Azzopardi effect
Small cell
55
Basophilic staining of vascular walls is also called
Azzopardi effect
56
Crush artifact
Small cell
57
Kulchitsky cells
Small cell
58
Amplify MYC
Small cell
59
Chromogranin marker
Small cell
60
Synaptophysin marker
Small cell
61
CD56 marker
Small cell
62
Small cell neuroendocrine markers
Chromogranin Synaptophysin CD56
63
Diagnosis of exclusion
Large cell
64
PTH
Squamous
65
Calcitonin
Small cell
66
Gonadotropins
Small cell
67
Describe Lambert eaton
Muscle weakness from auto antibodies to neuronal calcium channels
68
Example of hypercoagulable state
Trousseau's syndrome
69
Pulmonary osteoarthropathy is also called
Clubbing of fingers
70
Apical lung cancer called
Pancoast tumor
71
Horner syndrome caused by
Pancoast tumor (in apical lung) compressing on cervical sympathetic plexus
72
Signet ring cells
ALK
73
Acinus growth pattern in Asians
ALK
74
Positive for stain of calretinin
Mesothelioma

From Flashcardlet (411 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions