6.31/32 Anti-Parasitic Drugs

Question 1

prevents plasmodium parasites from making heme into hemozoin

Answer 1

chloroquine phosphate

quinine

Question 2

effective against malaria in RBCs, but not in liver

Answer 2

chloroquine phosphate

quinine

Question 3

has resistance because Plasmodium (malaria) can pump it out of its food vacuole

Answer 3

chloroquine phosphate

Question 4

not effective for P. falciparum outside of central america

Answer 4

chloroquine phosphate

Question 5

can cause neuropsychiatric effects (for malaria)

Answer 5

mefloquine

Question 6

malaria resistance exists in SE asia for

Answer 6

mefloquine

chloroquine

Question 7

ribosomal inhibition for malaria

Answer 7

doxycycline

Question 8

not for children <9 yrs

Answer 8

doxycycline

Question 9

cinchonism if used for malaria

Answer 9

quinine

Question 10

IV use causes severe hypoglycemia (for malaria)

Answer 10

quinine

Question 11

never give in buttocks of child (sciatic n. paralysis) for malaria

Answer 11

quinine

Question 12

DOC for uncomplicated malaria

Answer 12

atovaquone-proguanil

Question 13

used for pneumocystis carinii pneumonia if sulfa allergy

Answer 13

atovaquone

Question 14

for malaria within liver (p. vivax or ovale)

Answer 14

primaquine phosphate

Question 15

hemolysis with G6PD deficiency

Answer 15

primaquine phosphate

Question 16

free iron reduces peroxide bond, creating reactive oxygen radicals to kill malaria

Answer 16

artemisinin (which makes artemether-lumefantrin)

Question 17

mefloquine used how often for prophylaxis for malaria

Answer 17

weekly

Question 18

chloroquine phosphate used how often for prophylaxis for malaria

Answer 18

weekly

Question 19

doxycycline hyclate used how often for prophylaxis for malaria

Answer 19

daily

Question 20

atovoquone-proguanil used how often for prophylaxis for malaria

Answer 20

daily

Question 21

if pregnant and want prophylaxis for malaria, use

Answer 21

mefloquine

chloroquine

Question 22

if seizures and malaria, use

Answer 22

atovaquone-proguanil

Question 23

DOC for trichinosis (from eating raw meat, get muscle pain, fever, high eosinophil count)

Answer 23

albendazole

Question 24

DOC for ancylostoma (ground itch from sandbox or beach)

Answer 24

albendazole

Question 25

DOC for neurocysticercosis (use with steroid)

Answer 25

albendazole

Question 26

interferes with microtubule assembly impairs glucose uptake inhibits helminth specific enzyme fumarate reductase

Answer 26

albendazole

Question 27

DOC for toxicariasis

Answer 27

albendazole

Question 28

risk of fatal encephalitis if co-infected with loa loa (what is the medicine and what is the most likely infection)

Answer 28

ivermectin onchocerciasis (or strongyloides)

Question 29

DOC for onchocerciasis

Answer 29

ivermectin

Question 30

doc for strongyloides

Answer 30

ivermectin

Question 31

doc for mansonella ozzardi

Answer 31

ivermectin

Question 32

used in mass therapy for african river blindness

Answer 32

ivermectin

Question 33

opens Cl channels in invertebrates, not mammals!!!

Answer 33

ivermectin

Question 34

kills microfilaria but not adult worms

Answer 34

ivermectin | diethylcarbamazine

Question 35

doc for loa loa

Answer 35

diethylcarbamazine

Question 36

doc for wucheraria bancrofti and brugia malayi

Answer 36

diethylcarbamazine

Question 37

doc for m. streptocerca

Answer 37

diethylcarbamazine

Question 38

doc for tropical eosinophilia

Answer 38

diethylcarbamazine

Question 39

damages microfilarial surface membranes resulting in clearance by host immune response

Answer 39

diethylcarbamazine

Question 40

used with steroid (prednisone) to decrease side effects such as itching and rash

Answer 40

diethylcarbamazine

Question 41

doc for cutaneous leishmaniasis

Answer 41

pentavalent antimonials such as sodium stibugluconate and meglumine antimonate

Question 42

cutaneous and visceral leishmaniasis in india

Answer 42

milfetosine

Question 43

causes arrhythmias

Answer 43

pentavalent antimonials such as sodium stibugluconate and meglumine antimonate

Question 44

causes pancreatitis

Answer 44

pentavalent antimonials such as sodium stibugluconate and meglumine antimonate

Question 45

phlebotoxic

Answer 45

pentavalent antimonials such as sodium stibugluconate and meglumine antimonate

Question 46

for visceral leishmaniasis

Answer 46

liposoma ampho b

Question 47

DOC for schistosomiasis

Answer 47

praziquantel

Question 48

doc for flatworms (trematodes and cestodes)

Answer 48

praziquantel

Question 49

only non intestinal blood fluke that doesn't use praziquantel

Answer 49

fasciola hepatica (uses triclabendazole)

Question 50

blocks enzymes needed for folic acid synthesis

Answer 50

pyramethamine + sulfadiazine

Question 51

toxoplasmosis

Answer 51

pyramethamine + sulfadiazine

Question 52

for trichomonas vaginalis

Answer 52

metronidazole | tinidazole

Question 53

what should pt avoid if rx metronidazole or tinidazole

Answer 53

alcohol

Question 54

metallic taste

Answer 54

metronidazole

Question 55

which drug preferred for trichomonas vaginalis if pregnant

Answer 55

metronidazole