6.18 Bone Tumors

Question 1

Severe noctural pain relieved by NSAIDs

Answer 1

Osteoid osteoma

Question 2

Pain not relieved by NSAIDs

Answer 2

Osteoblastoma

Question 3

Random trabecular of woven bone rimmed w/ benign osteoblasts in loose CT stroma

Answer 3

Osteoid osteoma

Osteoblastoma

Question 4

Bimodal age distribution

Answer 4

Osteosarcoma

Question 5

Most common primary bone sarcoma

Answer 5

Osteosarcoma

Question 6

RB and p53 genes

Answer 6

Osteosarcoma

Question 7

Codman triangle

Answer 7

Osteosarcoma

Question 8

Pleomorphic and lace-like

Answer 8

Osteosarcoma

Question 9

EXT gene mutation

Answer 9

Osteochondroma

Question 10

Mushroom-shaped

Answer 10

Osteochondroma

Question 11

Most common benign bone tumor

Answer 11

Osteochondroma

Question 12

Ollier disease might have

Answer 12

Multiple (en)chondromas

Question 13

Maffuci syndrome might have

Answer 13

Multiple (en)chondromas

Question 14

Syndromes with multiple chondromas

Answer 14

Ollier disease

Maffuci syndrome

Question 15

X ray shows oval lesions with scalloped adjacent bone but intact cortex

Answer 15

Enchondroma

Question 16

Glistening tissue

Answer 16

Chondrosarcoma

Question 17

3 types of chondrosarcoma

Answer 17

Low grade
High grade
Dedifferentiated

Question 18

Small round cell bone tumor

Answer 18

Ewing Sarcoma and PNET

Question 19

t(11;22)

Answer 19

Ewing Sarcoma and PNET

Question 20

EWS-FLI1

Answer 20

Ewing Sarcoma and PNET

Question 21

Age <15

Answer 21

Ewing Sarcoma and PNET

Question 22

Diaphysis

Answer 22

Ewing Sarcoma and PNET

Question 23

Epiphysis

Answer 23

Giant Cell Tumor

Question 24

Large, red-brown tumor

Answer 24

Giant Cell Tumor

Question 25

Express high levels of RANKL (promotes proliferation of osteoclasts)

Answer 25

Giant cell tumor

Question 26

Multiloculated blood-filled cystic spaces

Answer 26

Aneurysmal Bone Cyst

Question 27

17p13 rearrangement

Answer 27

Aneurysmal Bone Cyst

Question 28

Upregulates matrix metalloproteases that lead to resorption of bone

Answer 28

Aneurysmal Bone Cyst

Question 29

Very common (50%) in children

Answer 29

Fibrous Cortical Defect

Question 30

Benign fibroblastic spindle cells with foamy or multinucleate histiocytes

Answer 30

Fibrous cortical defect | Non-ossifying fibroma

Question 31

Spindle cells in a storiform pattern

Answer 31

Fibrous cortical defect | Non-ossifying fibroma

Question 32

Fibro-osseous tumor

Answer 32

Fibrous dysplasia

Question 33

Chinese letters / c-shaped / alphabet soup

Answer 33

Fibrous dysplasia

Question 34

Curvy trabecular of woven bone lacking osteoblastic rimming in background of fibroblastic prolif

Answer 34

Fibrous dysplasia

Question 35

2 types of fibrous dysplasia

Answer 35

Monostotic (1 bone) | Polyostotic (>1 bone)

Question 36

Cranial and facial deformities common in

Answer 36

Polyostotic fibrous dysplasia

Question 37

Mets to bone usually from

Answer 37

Prostate Breast Kidney Lung