COX Inhibitors

Question 0

Longer half life than ibuprofen so good for night dosing for arthritis

Answer 0

Naproxen

Question 1

OTC

Answer 1

Ibuprofen

Naproxen

Question 2

Can cause blurred vision

Answer 2

Ibuprofen

Question 3

Serious and common side effects

Answer 3

Indomethacin

Question 4

Indomethacin is good for

Answer 4

Pericarditis
Closure of patent ductus
Gout

Question 5

More likely to cause peptic ulcers than other NSAIDS

Answer 5

Piroxicam

Question 6

Less likely to cause GI ulceration

Answer 6

Diclofenac
Etodolac
Celecoxib

Question 7

Topical gel for arthritis

Answer 7

Diclofenac

Question 8

Increase liver enzymes more than other NSAIDs

Answer 8

Diclofenac

Question 9

Regresses colorectal polyps

Answer 9

Sulindac

Celecoxib

Question 10

High rate of CNS effects

Answer 10

Sulindac

Question 11

Prodrug metabolized to active sulfide

Answer 11

Sulindac

Question 12

Enterohepatic recycling

Answer 12

Sulindac

Question 13

Can be used instead of morphine

Answer 13

Ketorolac

Question 14

Poor anti inflammatory effects

Answer 14

Ketorolac

Question 15

High risk of renal toxicity, so not used for more than 5 days & not used for renal impaired

Answer 15

Ketorolac

Question 16

Non acid NSAID

Answer 16

Nabumetone

Question 17

Prodrug that’s metabolized into a weak acid

Answer 17

Nabumetone

Question 18

Photo sensitivity side effect

Answer 18

Nabumetone

Question 19

Slightly greater affinity for COX 2 than 1

Answer 19

Etodolac

Question 20

Equal affinity for COX 1 and 2

Answer 20

Nabumetone

Question 21

COX2 inhibitors

Answer 21

Celecoxib

Meloxicam

Question 22

Increased risk of heart effects more than other NSAIDs

Answer 22

Celecoxib