Sleep Flashcards
(26 cards)
What are the wake centers
Tuberomammillary nucleus
Lateral hypothalamus
What is the sleep center
Ventrolateral preoptic nucleus
What does the ventrolateral preoptic nucleus secrete
GABA
What does the lateral hypothalamus secrete
Orexin
What does the tuberomammillary nucleus secrete?
Histamine
What does the raphe nucleus secrete
Serotonin
What does the locus ceruleus secrete
NE
What does the midbrain reticular formation secrete
ACh
What does the basal nucleus secrete
ACh
When you’re awake, what stimulates what?
LH and TMN stimulate LC and RN
When you’re asleep, what inhibits what?
VLPO inhibits LH and TMN
What state is the thalamus in when you’re awake
Depolarized relay mode
What state is your thalamus in while asleep
Hyperpolarized burst mode
Thalamus relay mode generates what EEG signals
High frequency beta and gamma waves
Thalamus burst mode generates what EEG signals
High amplitude delta
What causes transition from NREM to REM
When LC(NE) and RN(5HT) totally stop firing
- removes inhibition of pontine REM center (ACh)
- ACh depolarizes thalamic neurons (forebrain arousal)
- activate reticulospinal glycinergic neurons in medulla (muscle atonia)
Narcolepsy is cased by mutation in what gene
Orexin
Symptoms of narcolepsy
Excessive daytime sleepiness
Cataplexy (sudden loss of muscle tone while awake)
Sleep paralysis
REM sleep behavior disorder
- cause
- sxs
Causes by spill over if REM atonia into non REM
Person acts out dreams
Sleep walking is called
Somnambulism
Sleep terrors (which are in non REM) are called
Pavor nocturnus
Most prevalent sleep disorder
Obstructive sleep apnea
Types of sleeping pills
Benzodiazepines (diazepam) Z drugs (zolpidem, ambien, lunesta)
Mechanism of sleeping pills
Allosteric modulators of GABA A receptor
