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9 GI Flashcards

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1
Q

mystically dilated glands lined by parietal, chief, and foveolar cells

  • dx
  • associated with
A

fundic gland polyps

PPI use

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2
Q

diffuse foveolar hyperplasia

  • dx
  • cause
A

menetrier disease

excessive TGF alpha secretion

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3
Q

weight loss, diarrhea, peripheral edema

  • dx
A

menetrier disease

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4
Q

recurrent peptic ulcers and diarrhea

  • dx
A

zollinger-ellison / gastrinoma

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5
Q

FAP predisposes to what stomach stuff

A

fundic gland polyp

gastric adenoma

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6
Q

2 types of gastric carcinoma

A

intestinal

diffuse

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7
Q

CDH1 mutation associated with

A

gastric cancer

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8
Q

beta catenin assoc with what gastric cancer

A

intestinal gastric carcinoma

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9
Q

t(11;18) assoc with

A

MALT Lymphoma, MLT gene

RESISTANT TO THERAPY

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10
Q

lymphoepithelial lesions (dense lymphoplasmacytic infiltrate w/ lymphocytes in gastric epithelium)

A

gastric MALT lymphoma

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11
Q

salt and pepper chromatin in stomach

A

gastric carcinoid tumor

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12
Q

causes right sided cardiac valvular fibrosis

A

carcinoid syndrome

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13
Q

most common mesenchymal tumor in abdomen

A

GI stromal tumor

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14
Q

tumor originating from interstitial cell of cajal

A

GI stromal tumor

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15
Q

spindle cells, plump epithelioid cells

A

GI stromal tumor

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16
Q

CD117 cells

A

GI stromal tumor

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17
Q

imatinib used to treat

A

GI stromal tumor

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18
Q

cKIT

A

GI stromal tumor

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19
Q

full thickness ischemic necrosis

A

transmural infarction

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20
Q

surface erosion with crypt sparing

A

mucosal and mural infarction

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21
Q

person has steatorrhea - what could be the causes

A

pancreatic insufficiency

celiac

crohn disease

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22
Q

HLA DQ2 DQ8

A

celiac disease

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23
Q

anti-endomysial antibody

A

celiac

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24
Q

transglutaminase

A

celiac

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25
crypt hyeprplasia with villous atrophy
celiac
26
intraepithelial lymphocytes of CD8 T cells
celiac
27
celiac cancers
enteropathy associated T cell lymphoma small cell adenocarcinoma
28
autoAb to enterocytes and goblet cells
autoimmune enteropathy
29
FOXP3 gene
IPEX (imune dysregulation, polyendocrinopathy, enteropathy, X linkage), a type of autoimmune enteropathy
30
acanthocytes - dx - mutation
abetalipoproteinemia mutated microsomal triglyceride transfer protein (MTP)
31
vacuolated epithelial cells of small intestine
abetalipoproteinemia
32
mucin secreting gland in duodenum - dx - associated w/
brunner gland hyperplasia / adenoma duodenitis, ESRD, uremia
33
KRAS mutation
adenocarcinoma
34
what can cause adenocarcinoma of the small intestine
IBD celiac hereditary polyposis syndrome
35
serotonin elicits
peritumoral fibrosis vascular compression
36
carcinoid most aggressive if come from
midgut (ligament of treitz to terminal ileum or 2/3 trans colon
37
p-ANCA
positive in UC
38
Ab to saccharomyces cerevisiae
pos in crohn
39
aphthous ulcers
crohn
40
many lymphoid follicles - dx - tx
diversion colitis enemas w/ short chain fatty acids, re-anastamosis
41
incr intraepithelial lymphocytes and increased sub epithelial collagen
collagenous colitis (type of microscopic colitis)
42
increased intraepithelial lymphocytes w normal sub epithelial collagen - dx - association
lymphocytic colitis celiac, autoimmune or lymphocytic gastritis
43
apoptosis of crypt cells
GVHD
44
watery diarrhea
microscopic colitis GVHD
45
outpouchings regularly distributed along tenia coli
diverticulosis
46
thin wall of flattened or atrophic mucosa, decreased music propria, hypertrophy of circular layer of muscular is propria
diverticulosis
47
SMAD4
juvenile polyposis
48
RET
hirschsprung disease
49
congenital aganglionic megacolon - dx - assoc with
hirschsprung disease Down's
50
angiodysplasia associated with
aortic stenosis meckel
51
solitary rectal ulcer syndrome assoc with
inflammatory polyp
52
inflammatory polyp triad of sxs
rectal bleeding mucus discharge inflammatory lesion of ant rectal wall
53
fibromuscular hyperplasia
inflammatory polyp
54
piling up of goblet cells
hyperplasic polyp
55
if have juvenile polyposis, also have
pulmoary arterio-venous malformation
56
dilated glands with mucin and inflammatory debris
juvenile polyposis
57
PTEN
cowden bannayan-ruvalcaba-riley
58
macrocephaly, intestinal hamartomatous polyps, benign skin tumors - dx - predisposed to
cowden syndrome BRCA follicular CA of thyroid endometrial CA
59
multiple trichilemmomas
cowden
60
mental deficiencies and developmental delays
bannayan-ruvalcaba-riley
61
nail abnormalities
cronkhite-canada syndrome
62
adenoma defined by
epithelial dysplasia
63
can cause hypoproteinemic hypokalemia
adenoma
64
nuclear hyperchromasia, elongation, stratification
epithelial dysplasia (adenoma)
65
sessile serrated adenomas more common in
right colon
66
full length serration
sessile serrated adenoma
67
what is pseudomyxoma peritonei
invasion of mutinous cystadenocarcinoma thru appendix wall
68
yellow tumor
carcinoid
69
dilated appendix filled w/ mucin
mucocele
70
FAP mutations
APC KRAS p53 (MUTYH)
71
HNPCC mutations
MSH2 MLH1 BRAF
72
serration just at surface
hyperplastic polyp
73
FAP extraint manifest
congenital hypertrophy of retinal pigment epithelium
74
colonic adenomas, osteomas, epidermal cysts, desmoid tumors
gardner syndrome (type of FAP)
75
intestinal adenomas and tumors of the CNS
turcot syndrome (type of FAP)
76
most common malignancy of GI tract
adenocarcinoma of colon
77
if have sessile serrated adenomas, mutinous differentiation, and peritumoral lymphocytes, probably
HNPCC
78
cloacogenic carcinoma - also called - located where
basaloid SCC anal canal

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