4.23 path derm 2

Question 0

Macules and papilla of hypopigmentation

Answer 0

Vitiligo

Question 1

Autoimmune destruction of melanocytes

Answer 1

Vitiligo

Question 2

Absent melanocytes

Answer 2

Vitiligo

Question 3

Melanocytes present but don’t produce enough melanin

Answer 3

Albinism

Question 4

Tyrosinase defect

Answer 4

Albinism

Question 5

Abnormal melanocyte migration

Answer 5

Albinism

Question 6

Associated with pregnancy and oral contraceptives

Answer 6

Melasma

Question 7

Labial melanocytic macule associated with

Answer 7

Peutz-jeghers disease

Question 8

Peutz-jeghers disease is associated with

Answer 8

Labial melanocytic macule

Question 9

Melanocytic hyperplasia

Answer 9

Lentigo

Question 10

3 types of melanocytic nevi

Answer 10

Junctional
Compound
Intradermal

Question 11

Red pink nodule

Answer 11

Spitz nevus / spindle and epithelioid cell nevus

Question 12

Blue to black macule

Answer 12

Blue nevus

Question 13

White rim around nevus

Answer 13

Halo nevus

Question 14

Halo nevus adolescent vs old

Answer 14

Adolescent benign

>40 could be melanoma

Question 15

Nevi molecules

Answer 15

Mutations in BRAF or RAS

Dysplasic nevi don’t make p16 or CDK4/6

Question 16

Melanoma molecules

Answer 16

Mutations in RAS BRAF and MEK

Question 17

Med for melanoma and what it inhibits

Answer 17

Vemurafenib

BRAF

Question 18

ABCDE of melanoma

Answer 18

Asymmetry
Border
Color
Diameter (>6mm)
Evolution

Question 19

Depth of invasion is also called

Answer 19

Breslow depth

Question 20

Most important prognostic feature of melanoma

Answer 20

Depth of invasion / brea low depth

Question 21

How to measure depth of invasion

Answer 21

Granular cell layer to base of tumor

Question 22

Level (not depth) of invasion

Answer 22

Clark level

Question 23

Upward pagetoid spread of atypical melanocytes

Answer 23

Melanoma in situ

Question 24

Patterns of spread

Answer 24

Vertical worse than horizontal

Question 25

Vertical growing melanoma

Answer 25

Nodular melanoma

Question 26

Treatment of melanoma

Answer 26

Early detection | Complete excision

Question 27

Stuck on brown to tan papules

Answer 27

Seborrheic keratosis

Question 28

Velvety thick hyper pigmented skin

Answer 28

Acanthosis nigricans

Question 29

Skin tag called

Answer 29

Fibroepithelial polyp

Question 30

Common in pregnancy

Answer 30

Melasma | Fibroepithelial polyp

Question 31

Firm and movable with keratin debris

Answer 31

Epidermal inclusion cyst

Question 32

Rupture can lead to inflammation and pain

Answer 32

Epidermal inclusion cyst

Question 33

Muir Torre syndrome comprised of

Answer 33

Sebaceous adenomas