Chemo drugs Flashcards by Lu Chen

Q

What drugs have immunosuppressant effects

A

Cyclophosphamide

Ifosfamide

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Q

Alkylating agents

A

Cyclophosphamide

Ifosfamide

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Q

What do you give to patients taking cyclophosphamide or ifosfamide to decrease bladder toxicity

A

Hydration and MESNA

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Q

Big ADR of cisplatin

A

100% will vomit

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Q

DNA binding agents

A

Cisplatin

Carboplatin

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Q

Antimetabolites

A

Cytarabine
Methotrexate
5-FU

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Q

Mechanism of cytarabine

A

Inhibits DNA polymerase

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Q

Mechanism of methotrexate

A

Inhibits dihydrofolate reductase

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Q

Mechanism of 5-FU

A

Inhibits thymidylate synthase

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Q

Can be given intrathecally

A

Methotrexate

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Q

If high dose of methotrexate, may need

A

Leukovorin rescue

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Q

Competes with folic acid

A

Methotrexate

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Q

What helps accumulate methotrexate in cells

A

Poly glutamate

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Q

Causes chest pain

A

Cytarabine

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Q

Works in S phase

A

Cytarabine

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Q

Cyclophosphamide is an

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A

Alkylating agent

Q

Ifosfamide is an

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A

Alkylating agent

Q

Cisplatin is a

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A

DNA binding agent

Q

Carboplatin is a

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A

DNA binding agent

Q

Cytarabine is an

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A

Antimetabolite

Q

Methotrexate is an

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A

Antimetabolite

Q

5-FU is an

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A

Antimetabolite

Q

Anti tumor antibiotic

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A

Doxorubicin

Q

Causes cardiac problems

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A

Doxorubicin

Need acne like rash to work

Erlotinib

Interactions with cigarettes and omeprazole

Erlotinib

Decreased LVEF

Sunitinib

Signal transduction inhibitors

Imatinib Erlotinib Sunitinib Temsirolimus

Differentiating agents

Arsenic trioxide | Tretinoin

Protease inhibitors

Bortezomid | Carfizomib

Endocrine drugs

Tamoxifen Anastrozole Bicalutamide Leuprolide

Anti-angiogenesis (monoclonal Ab)

Bevaclizumab

Targets oncogenes (monoclonal Ab)

Cetuximab | Trastuzumab

Immuno-regulatory mechanism (monoclonal Ab)

Ipilimumab Pembrolizumab Rituximab

Hematopoietic

Erythropoietin Filgrastim Pegfilgrastim