Human Function 8

Question 0

2 roles of platelets

Answer 0

1) form plugs

2) secrete chemicals for clotting and tissue repair

Question 1

3 phases of hemostasis

Answer 1

1) procoagulation phase
2) anticoagulation phase
3) fibrinolysis phase

Question 2

3 steps in formation of platelet plug

Answer 2

1) adhesion - to subendothelial vWF & collagen
2) activation - release TxA2 and ADP
3) aggregation - bind fibrinogen to help platelet aggregation

Question 3

How 81ASA and plavix prevent blood clots

Answer 3

They are suicide inactivators of COX, so they inhibit TxA2 synthesis
Plavix also antagonizes ADP in promoting platelet aggregation

Question 4

Clotting factors are made by the…

Answer 4

Liver

Question 5

Which clotting factor is made in endothelial cells?

Answer 5

Factor 8

Question 6

Purpose of intrinsic and extrinsic pathway

Answer 6

Activate Factor X (10)

Question 7

Diagnostic tests for blood coagulation pathways

Answer 7

PT - extrinsic
PTT - intrinsic
PT/INR - standardize PTs across labs

Question 8

Clotting factors and Hemophilia

Answer 8

Hemophilia A - FVIII (8)

Hemophilia B - FIX (9)

Question 9

What causes activation of extrinsic pathway?

Answer 9

Vessel injury –> exposed subendothelial tissue factor (III) –> bind and activate FVII (7)

Question 10

Which factors are involved in both intrinsic and extrinsic pathway of blood clotting?

Answer 10

FVII (7)

FX (10)

Question 11

Non enzymatic protein factors in clotting cascade

Answer 11

FVIII (8)

FV (5)

Question 12

Thrombin also activates previous factors…

Answer 12

FVII (7)
FVIII (8)
FV (5)

Question 13

What is also produced when thrombin converts fibrinogen to fibrin?

Answer 13

2 FpA and 2 FpB

Question 14

Why is fibrinogen soluble and fibrin not?

Answer 14

Fibrinogen has the fibrinopeptides (FpA, FpB) that have high density of negative charges

Question 15

What gives the fibrinopeptides FpA and FpB high density of negative charges?

Answer 15

Asp
Glu
Tyr-sulfate (SO3)-

Question 16

Hard clot formation caused by what enzyme?

Answer 16

Transglutaminase (FXIII-13)

Question 17

What two amino acids are used in crosslink to form hard clot?

Answer 17

Lys

Glen

Question 18

What type of bond is made in hard clot?

Answer 18

Amide bond